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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FNIP2 Antibody (C-term)   

FNIP2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FNIP2 Antibody (C-term) AP10654B
    FNIP2 Antibody (C-term) (Cat. #AP10654b) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the FNIP2 antibody detected the FNIP2 protein (arrow).
  • IHC-P - FNIP2 Antibody (C-term) AP10654B
    FNIP2 antibody (C-term) (Cat. #AP10654b) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the FNIP2 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - FNIP2 Antibody (C-term) AP10654B
    FNIP2 Antibody (C-term) (Cat. #AP10654b) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9P278
Other Accession NP_065891.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 122115 Da
Antigen Region 776-804 aa
Additional Information
Gene ID 57600
Other Names Folliculin-interacting protein 2, FNIP1-like protein, O6-methylguanine-induced apoptosis 1 protein, FNIP2, FNIPL, KIAA1450, MAPO1
Target/Specificity This FNIP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 776-804 amino acids from the C-terminal region of human FNIP2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFNIP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FNIP2
Synonyms FNIPL, KIAA1450, MAPO1
Function Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1 (PubMed:27353360). May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine- mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways (PubMed:18403135). May regulate phosphorylation of RPS6KB1 (PubMed:18663353).
Cellular Location Cytoplasm Note=Colocalizes with FLCN in the cytoplasm
Tissue Location Widely expressed with highest levels in muscle, nasal mucosa, salivary gland, uvula, fat, liver, heart, placenta and pancreas. Moderately expressed in the lung, small intestine, kidney and brain. Lower levels detected in renal cell carcinoma than in normal kidney tissue (PubMed:18403135). Higher levels detected in oncocytoma tumors than in normal kidney. Higher levels detected in renal cell carcinoma tumors than in normal kidney tissue (PubMed:27353360).
Research Areas
Citations (0)

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Rose, J. Phd, et al. Mol. Med. (2010) In press :
Hasumi, H., et al. Gene 415 (1-2), 60-67 (2008) :

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Cat# AP10654B
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