|Application ||WB, E|
|Other Accession||Q99PV8, NP_612808.1, NP_075049.1|
|Calculated MW||95519 Da|
|Antigen Region||307-334 aa|
|Other Names||B-cell lymphoma/leukemia 11B, BCL-11B, B-cell CLL/lymphoma 11B, COUP-TF-interacting protein 2, Radiation-induced tumor suppressor gene 1 protein, hRit1, BCL11B, CTIP2, RIT1|
|Target/Specificity||This BCL11B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-334 amino acids from the Central region of human BCL11B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BCL11B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Key regulator of both differentiation and survival of T- lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T- lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC- rich response element (By similarity). May also function in the P53-signaling pathway (By similarity).|
|Tissue Location||Highly expressed in brain and in malignant T- cell lines derived from patients with adult T-cell leukemia/lymphoma|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.
Ganguli-Indra, G., et al. Exp. Dermatol. 18(11):994-996(2009)
Cherrier, T., et al. Oncogene 28(38):3380-3389(2009)
Ganguli-Indra, G., et al. PLoS ONE 4 (4), E5367 (2009) :
Cismasiu, V.B., et al. Virology 380(2):173-181(2008)
Desplats, P.A., et al. Neurobiol. Dis. 31(3):298-308(2008)
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