|Application ||WB, FC, E|
|Calculated MW||101976 Da|
|Antigen Region||418-446 aa|
|Other Names||Probable leucine--tRNA ligase, mitochondrial, Leucyl-tRNA synthetase, LeuRS, LARS2, KIAA0028|
|Target/Specificity||This LARS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 418-446 amino acids from the Central region of human LARS2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LARS2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Mitochondrion matrix.|
|Tissue Location||Ubiquitously expressed, but highest expression in tissues with high metabolic rates, such as skeletal muscle, heart, and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid.
Li, R., et al. Mol. Cell. Biol. 30(9):2147-2154(2010)
Reiling, E., et al. Diabetologia 53(1):103-110(2010)
Zhou, W., et al. Acta Biochim. Biophys. Sin. (Shanghai) 41(1):54-62(2009)
Park, H., et al. RNA 14(11):2407-2416(2008)
't Hart, L.M., et al. Diabetes 54(6):1892-1895(2005)
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