|Application ||WB, IHC-P, FC, IF, E|
|Other Accession||Q99KK7, NP_005691|
|Calculated MW||82589 Da|
|Antigen Region||583-612 aa|
|Other Names||Dipeptidyl peptidase 3, Dipeptidyl aminopeptidase III, Dipeptidyl arylamidase III, Dipeptidyl peptidase III, DPP III, Enkephalinase B, DPP3|
|Target/Specificity||This DPP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 583-612 amino acids from the C-terminal region of human DPP3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DPP3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:3233187, PubMed:1515063). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:9425109, PubMed:3233187, PubMed:11209758).|
|Cellular Location||Cytoplasm, cytosol|
|Tissue Location||Detected in placenta (at protein level) (PubMed:3233187). Detected in erythrocytes (at protein level) (PubMed:1515063).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternate transcriptional splice variants have been characterized.
Shukla, A.A., et al. FEBS J. 277(8):1861-1875(2010)
Salopek-Sondi, B., et al. Biol. Chem. 389(2):163-167(2008)
Gevaert, K., et al. Proteomics 5(14):3589-3599(2005)
Abramic, M., et al. Int. J. Biochem. Cell Biol. 36(3):434-446(2004)
Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :
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