|Application ||WB, IHC-P, FC, E|
|Calculated MW||56751 Da|
|Antigen Region||8-36 aa|
|Other Names||Recombining binding protein suppressor of hairless-like protein, Transcription factor RBP-L, RBPJL, RBPL, RBPSUHL|
|Target/Specificity||This RBPJL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-36 amino acids from the N-terminal region of human RBPJL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RBPJL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Putative transcription factor, which cooperates with EBNA2 to activate transcription.|
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Provided below are standard protocols that you may find useful for product applications.
In mouse, recombining binding protein L (RBP-L) is a transcription factor that binds to DNA sequences almost identical to that bound by the Notch receptor signalling pathway transcription factor RBP-J. However, unlike RBP-J, RBP-L does not interact with Notch receptors. RBP-L has been shown to activate transcription in concert with Epstein-Barr virus nuclear antigen-2 (EBNA2). The protein encoded by this gene is similar in sequence to the mouse RPB-L protein and Drosophila suppressor of hairless protein.
Beres, T.M., et al. Mol. Cell. Biol. 26(1):117-130(2006)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Nakagawa, H., et al. Oncogene 19(2):210-216(2000)
Tani, S., et al. J. Hum. Genet. 44(1):73-75(1999)
Minoguchi, S., et al. Mol. Cell. Biol. 17(5):2679-2687(1997)
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