|Application ||WB, IHC-P, IF, E|
|Other Accession||Q8VHW3, NP_114103.2|
|Calculated MW||28129 Da|
|Antigen Region||108-136 aa|
|Other Names||Voltage-dependent calcium channel gamma-6 subunit, Neuronal voltage-gated calcium channel gamma-6 subunit, CACNG6|
|Target/Specificity||This CACNG6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-136 amino acids from the Central region of human CACNG6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CACNG6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in heart left ventricle.|
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Provided below are standard protocols that you may find useful for product applications.
Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). Alternative splicing results in multiple transcript variants. Variants in this gene have been associated with aspirin-intolerant asthma.
Lee, J.S., et al. BMC Med. Genet. 11, 138 (2010) :
Chen, R.S., et al. Cell Biochem. Biophys. 47(2):178-186(2007)
Chu, P.J., et al. Gene 280 (1-2), 37-48 (2001) :
Burgess, D.L., et al. Genomics 71(3):339-350(2001)
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