|Application ||WB, IHC-P, FC, E|
|Other Accession||Q8BZM1, NP_444504.1|
|Calculated MW||68208 Da|
|Antigen Region||498-525 aa|
|Other Names||Glomulin, FK506-binding protein-associated protein, FAP, FKBP-associated protein, GLMN, FAP48, FAP68, VMGLOM|
|Target/Specificity||This GLMN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 498-525 amino acids from the C-terminal region of human GLMN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GLMN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FAP48, FAP68, VMGLOM|
|Function||Essential for normal development of the vasculature. May represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12. May function as an membrane anchoring protein. Isoform 1 may stimulate the p70S6K pathway. Isoform 2 may inhibit cell proliferation and increase IL2 production.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq].
Arai, T., et al. Proc. Natl. Acad. Sci. U.S.A. 100(17):9855-9860(2003)
Brouillard, P., et al. Clin. Genet. 63(5):340-351(2003)
Krummrei, U., et al. Proc. Natl. Acad. Sci. U.S.A. 100(5):2444-2449(2003)
Brouillard, P., et al. Am. J. Hum. Genet. 70(4):866-874(2002)
Grisendi, S., et al. J. Biol. Chem. 276(49):46632-46638(2001)
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