|Application ||WB, IHC-P, E|
|Calculated MW||58129 Da|
|Antigen Region||10-37 aa|
|Other Names||Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform, CAM-PRP catalytic subunit, Calcineurin, testis-specific catalytic subunit, Calmodulin-dependent calcineurin A subunit gamma isoform, PPP3CC, CALNA3, CNA3|
|Target/Specificity||This PPP3CC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-37 amino acids from the N-terminal region of human PPP3CC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PPP3CC Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32.|
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Provided below are standard protocols that you may find useful for product applications.
Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha (CALNA1; MIM 114105), calcineurin A-beta (CALNA2; MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).
Liu, Y.J., et al. Obesity (Silver Spring) 18(12):2339-2346(2010)
He, Z.H., et al. Eur. J. Appl. Physiol. 110(4):761-767(2010)
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)
Kyogoku, C., et al. Psychiatry Res (2010) In press :
Pelak, K., et al. J. Infect. Dis. 201(8):1141-1149(2010)
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