|Application ||WB, E|
|Other Accession||B0K025, Q78XF5, Q7ZWJ3, Q5ZJR3, Q2KID7, Q5M9B7, NP_067050.1|
|Predicted||Xenopus, Bovine, Chicken, Zebrafish, Rat|
|Calculated MW||16829 Da|
|Antigen Region||90-117 aa|
|Other Names||Oligosaccharyltransferase complex subunit OSTC, Hydrophobic protein HSF-28, OSTC|
|Target/Specificity||This OSTC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-117 amino acids from the C-terminal region of human OSTC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OSTC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as substrate-specific component of the N- oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X- Ser/Thr consensus motif in nascent polypeptide chains. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.|
|Cellular Location||Endoplasmic reticulum. Membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)
Shibatani, T., et al. Biochemistry 44(16):5982-5992(2005)
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