|Application ||IHC-P, WB, E|
|Other Accession||NP_116571.1, NP_116569.1|
|Calculated MW||93073 Da|
|Antigen Region||624-653 aa|
|Other Names||Carbohydrate-responsive element-binding protein, ChREBP, Class D basic helix-loop-helix protein 14, bHLHd14, MLX interactor, MLX-interacting protein-like, WS basic-helix-loop-helix leucine zipper protein, WS-bHLH, Williams-Beuren syndrome chromosomal region 14 protein, MLXIPL, BHLHD14, MIO, WBSCR14|
|Target/Specificity||This MLXIPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 624-653 amino acids from the C-terminal region of human MLXIPL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MLXIPL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BHLHD14, MIO, WBSCR14|
|Function||Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity).|
|Tissue Location||Expressed in liver, heart, kidney, cerebellum and intestinal tissues|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23.
Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)
Johansen, C.T., et al. Nat. Genet. 42(8):684-687(2010)
Keebler, M.E., et al. Circ Cardiovasc Genet 3(4):358-364(2010)
Chidambaram, M., et al. Metab. Clin. Exp. (2010) In press :
Reynolds, C.A., et al. Hum. Mol. Genet. 19(10):2068-2078(2010)
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