|Application ||WB, IHC-P, E|
|Other Accession||Q58D15, NP_912730.2, NP_115935.3|
|Calculated MW||40301 Da|
|Antigen Region||1-30 aa|
|Other Names||Tripartite motif-containing protein 54, Muscle-specific RING finger protein, MuRF, Muscle-specific RING finger protein 3, MuRF-3, MuRF3, RING finger protein 30, TRIM54, MURF, MURF3, RNF30|
|Target/Specificity||This TRIM54 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TRIM54.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRIM54 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MURF, MURF3, RNF30|
|Function||May bind and stabilize microtubules during myotubes formation.|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line Note=Associates with microtubules. Localizes to the Z-lines in skeletal muscles (By similarity).|
|Tissue Location||Specifically expressed in heart and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq].
Centner, T., et al. J. Mol. Biol. 306(4):717-726(2001)
Spencer, J.A., et al. J. Cell Biol. 150(4):771-784(2000)
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