|Application ||WB, E|
|Other Accession||NP_940798.1, NP_079173.2|
|Calculated MW||37989 Da|
|Antigen Region||283-312 aa|
|Other Names||Progestin and adipoQ receptor family member 6, Progestin and adipoQ receptor family member VI, PAQR6|
|Target/Specificity||This PAQR6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-312 amino acids from the C-terminal region of human PAQR6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PAQR6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432, PubMed:23161870). Seems to act through a G(s) mediated pathway (PubMed:23161870). Involved in neurosteroid inhibition of apoptosis (PubMed:23161870). May be involved in regulating rapid P4 signaling in the nervous system (PubMed:23763432). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23763432, PubMed:23161870).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Brain specific (PubMed:16044242, PubMed:23763432). Highly expressed in the hypothalamus, also expressed in forebrain, amygdala, corpus callosum and spinal cord (PubMed:23161870).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The function of this protein remains unknown.
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)
Smith, J.L., et al. Steroids 73(11):1160-1173(2008)
Tang, Y.T., et al. J. Mol. Evol. 61(3):372-380(2005)
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