- CITATIONS: 1
|Application ||FC, WB, E|
|Other Accession||P49001, P21274, Q90751, NP_001191.1|
|Predicted||Chicken, Mouse, Rat|
|Calculated MW||44702 Da|
|Antigen Region||260-289 aa|
|Other Names||Bone morphogenetic protein 2, BMP-2, Bone morphogenetic protein 2A, BMP-2A, BMP2, BMP2A|
|Target/Specificity||This BMP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-289 amino acids from the Central region of human BMP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BMP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).|
|Tissue Location||Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine|
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation.
Liu, Y., et al. Clin. Orthop. Relat. Res. 468(12):3333-3341(2010)
Kupfer, S.S., et al. Gastroenterology 139(5):1677-1685(2010)
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010)
Szczesny, G., et al. Arch Orthop Trauma Surg (2010) In press :
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