|Application ||WB, E|
|Calculated MW||148099 Da|
|Antigen Region||300-329 aa|
|Other Names||Myosin-IIIb, Myo3b|
|Target/Specificity||This Mouse Myo3b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-329 amino acids from the N-terminal region of mouse Myo3b.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Myo3b Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable actin-based motor with a protein kinase activity (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern (PubMed:26754646). Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (PubMed:22264607).|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection, stereocilium|
|Tissue Location||Expressed in the cochlear hair cells (at protein level) (PubMed:26754646). Expressed in utricle hair bundles (at protein level) (PubMed:26926603)|
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Provided below are standard protocols that you may find useful for product applications.
Probable actin-based motor with a protein kinase activity (By similarity).
Katti, C., et al. Exp. Eye Res. 89(2):224-237(2009)
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