|Application ||WB, E|
|Calculated MW||25919 Da|
|Antigen Region||51-79 aa|
|Other Names||Ribosyldihydronicotinamide dehydrogenase [quinone], NRH dehydrogenase [quinone] 2, NRH:quinone oxidoreductase 2, Quinone reductase 2, QR2, NQO2, NMOR2|
|Target/Specificity||This NQO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-79 amino acids from the N-terminal region of human NQO2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NQO2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.|
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Provided below are standard protocols that you may find useful for product applications.
NQO2 (EC 220.127.116.11) is a flavoprotein that catalyzes the 2-electron reduction of various quinones, redox dyes, and the vitamin K menadione. NQO2 predominantly uses dihydronicotinamide riboside (NRH) as the electron donor (summary by Wu et al., 1997 [PubMed 9367528]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Ji, L.D., et al. J. Pineal Res. 48(2):133-141(2010)
Yu, K.D., et al. Breast Cancer Res. Treat. 118(3):647-649(2009)
Choi, J.Y., et al. Clin. Cancer Res. 15(16):5258-5266(2009)
Yu, K.D., et al. Hum. Mol. Genet. 18(13):2502-2517(2009)
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