|Application ||WB, IF, FC, E|
|Other Accession||NP_001002033.1, NP_057269.1|
|Calculated MW||16015 Da|
|Antigen Region||58-86 aa|
|Other Names||Hematological and neurological expressed 1 protein, Androgen-regulated protein 2, Hematological and neurological expressed 1 protein, N-terminally processed, HN1, ARM2|
|Target/Specificity||This HN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the Central region of human HN1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HN1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR- signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408).|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta|
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Provided below are standard protocols that you may find useful for product applications.
HN1 belongs to the HN1 family.
Laughlin, K.M., et al. Pathol. Oncol. Res. 15(3):437-444(2009)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Zougman, A., et al. J. Proteome Res. 5(4):925-934(2006)
Zhou, G., et al. Gene 331, 115-123 (2004) :
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