|Application ||WB, E|
|Calculated MW||40464 Da|
|Antigen Region||326-354 aa|
|Other Names||Membrane progestin receptor beta, mPR beta, Lysosomal membrane protein in brain 1, Progestin and adipoQ receptor family member 8, Progestin and adipoQ receptor family member VIII, PAQR8, C6orf33, LMPB1, MPRB|
|Target/Specificity||This PAQR8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326-354 amino acids from the C-terminal region of human PAQR8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PAQR8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (By similarity). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Note=Colocalizes with a lysosomal protein CTSD/cathepsin D.|
|Tissue Location||Highly expressed in the hypothalamus (PubMed:23161870). Also expressed in spinal cord, kidney and testis.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
PAQR8 is steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity).
Smith, J.L., et al. Steroids 73(11):1160-1173(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Tang, Y.T., et al. J. Mol. Evol. 61(3):372-380(2005)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Hammes, S.R. Proc. Natl. Acad. Sci. U.S.A. 100(5):2168-2170(2003)
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