|Application ||WB, IHC-P, IF, FC, E|
|Other Accession||Q9QYV8, P54099, NP_001119603.1, NP_002684.1|
|Calculated MW||139562 Da|
|Antigen Region||1120-1148 aa|
|Other Names||DNA polymerase subunit gamma-1, Mitochondrial DNA polymerase catalytic subunit, PolG-alpha, POLG, MDP1, POLG1, POLGA|
|Target/Specificity||This POLG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1120-1148 amino acids from the C-terminal region of human POLG.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||POLG Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MDP1, POLG1, POLGA|
|Function||Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.|
|Cellular Location||Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.
Tong, Z.B., et al. Fertil. Steril. 94(7):2932-2934(2010)
Stewart, J.D., et al. Hepatology 52(5):1791-1796(2010)
Batabyal, D., et al. J. Biol. Chem. 285(44):34191-34201(2010)
Wang, W., et al. Nucleic Acids Res. (2010) In press :
Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)
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