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Hippocalcin Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

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  • WB - Hippocalcin Antibody (N-term) AP1564a
    Western blot analysis of lysate from human brain tissue lysate, using Hippocalcin Antibody (R17)(Cat. #AP1564A). AP1564A was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.
  • IHC-P - Hippocalcin Antibody (N-term) AP1564a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
  • IHC-P - Hippocalcin Antibody (N-term) AP1564a
    Formalin-fixed and paraffin-embedded human brain tissue reacted with Hippocalcin antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P84074
Other Accession P84076, Q06AT1, P84075, Q4PL64
Reactivity Human, Mouse
Predicted Bovine, Pig, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 22427 Da
Antigen Region 2-32 aa
Additional Information
Gene ID 3208
Other Names Neuron-specific calcium-binding protein hippocalcin, Calcium-binding protein BDR-2, HPCA, BDR2
Target/Specificity This Hippocalcin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human Hippocalcin.
Dilution WB~~1:1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHippocalcin Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HPCA (HGNC:5144)
Synonyms BDR2
Function Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (PubMed:28398555). May also play a role in cyclic-nucleotide- mediated signaling through the regulation of adenylate and guanylate cyclases (By similarity).
Cellular Location Cytoplasm, cytosol {ECO:0000250|UniProtKB:P84076, ECO:0000269|PubMed:28398555} Membrane {ECO:0000250|UniProtKB:P84076}; Peripheral membrane protein {ECO:0000250|UniProtKB:P84076}. Note=Association with membranes is calcium-dependent (By similarity). Enriched in the perinuclear region, probably at the trans Golgi network in response to calcium (PubMed:28398555) {ECO:0000250|UniProtKB:P84076, ECO:0000269|PubMed:28398555}
Tissue Location Brain specific..
Research Areas
Citations ( 0 )


Hippocalcin is a member of neuron-specific calcium-binding proteins family found in the retina and brain. This protein is associated with the plasma membrane. It has similarities to proteins located in the photoreceptor cells that regulate photosignal transduction in a calcium-sensitive manner. This protein displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. It is identical to the rat and mouse hippocalcin proteins and thought to play an important role in neurons of the central nervous system in a number of species.


Takamatsu, K., et al., Biochem. Biophys. Res. Commun. 200(1):606-611 (1994).
Hidaka, H., et al., Neurosci. Res. 16(2):73-77 (1993).
Kobayashi, M., et al., Biochem. Biophys. Res. Commun. 189(1):511-517 (1992).
Masaki, T., et al., Gene 225 (1-2), 117-124 (1998).
Ivings, L., et al., Biochem. J. 363 (Pt 3), 599-608 (2002).

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$ 325.00
$ 109.00
Cat# AP1564a
Availability: In Stock
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