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MRC2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MRC2 Antibody (Center) AP16060c
    MRC2 Antibody (Center) (Cat. #AP16060c) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MRC2 antibody detected the MRC2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UBG0
Other Accession NP_006030.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 166674 Da
Antigen Region 798-827 aa
Additional Information
Gene ID 9902
Other Names C-type mannose receptor 2, C-type lectin domain family 13 member E, Endocytic receptor 180, Macrophage mannose receptor 2, Urokinase-type plasminogen activator receptor-associated protein, UPAR-associated protein, Urokinase receptor-associated protein, CD280, MRC2, CLEC13E, ENDO180, KIAA0709, UPARAP
Target/Specificity This MRC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 798-827 amino acids from the Central region of human MRC2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMRC2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MRC2
Synonyms CLEC13E, ENDO180, KIAA0709, UPARAP
Function May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon Expressed in endothelial cells, fibroblasts and macrophages Highly expressed in fetal lung and kidney
Research Areas
Citations (0)

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MRC2 is a recycling endocytic receptor that functions in cell motility and remodeling of the extracellular matrix by promoting cell migration and uptake of collagens for intracellular degradation (Wienke et al., 2007 [PubMed 17974964]).[supplied by OMIM].


Messaritou, G., et al. J. Cell. Sci. 122 (PT 22), 4042-4048 (2009) :
Wu, X., et al. Cancer Prev Res (Phila Pa) 2(7):617-624(2009)
Wienke, D., et al. Cancer Res. 67(21):10230-10240(2007)
Sulek, J., et al. J. Histochem. Cytochem. 55(4):347-353(2007)
Johnson, J.M., et al. Science 302(5653):2141-2144(2003)

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$ 325.00
$ 109.00
Cat# AP16060c
Availability: In Stock
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