|Application ||WB, E|
|Other Accession||Q923G5, Q91WU6, NP_001139020.1, NP_060210.2|
|Calculated MW||35140 Da|
|Antigen Region||240-267 aa|
|Other Names||Palmitoyltransferase ZDHHC7, Zinc finger DHHC domain-containing protein 7, DHHC-7, Zinc finger protein 370, ZDHHC7, ZNF370|
|Target/Specificity||This ZDHC7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 240-267 amino acids from the C-terminal region of human ZDHC7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZDHC7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95 (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity).|
|Cellular Location||Golgi apparatus membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and regulate their synaptic clustering and/or cell surface stability (By similarity).
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
Lehner, B., et al. Genomics 83(1):153-167(2004)
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