|Application ||WB, E|
|Calculated MW||60183 Da|
|Antigen Region||65-93 aa|
|Other Names||Tether containing UBX domain for GLUT4, Alveolar soft part sarcoma chromosomal region candidate gene 1 protein, Alveolar soft part sarcoma locus, Renal papillary cell carcinoma protein 17, UBX domain-containing protein 9, ASPSCR1, ASPL, RCC17, TUG, UBXD9, UBXN9|
|Target/Specificity||This ASPSCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-93 amino acids from the N-terminal region of human ASPSCR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ASPSCR1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ASPL, RCC17, TUG, UBXD9, UBXN9|
|Function||Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT.|
|Cellular Location||Endomembrane system; Peripheral membrane protein. Endoplasmic reticulum- Golgi intermediate compartment membrane; Peripheral membrane protein Cytoplasm. Nucleus|
|Tissue Location||Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a candidate gene for alveolar soft part sarcoma (ASPS). It has been found that this gene is fused with transcription factor TFE3 gene in ASPS and also in renal cell carcinomas. Several alternatively spliced transcript variants of this gene have been described, but their full length nature has not been determined.
Ban, H.J., et al. BMC Genet. 11, 26 (2010) :
Alexandru, G., et al. Cell 134(5):804-816(2008)
Vistica, D.T., et al. J. Pediatr. Hematol. Oncol. 30(1):46-52(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Bogan, J.S., et al. Nature 425(6959):727-733(2003)
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