|Application ||WB, E|
|Other Accession||Q810C0, NP_115928.1|
|Calculated MW||95404 Da|
|Antigen Region||773-801 aa|
|Other Names||SLIT and NTRK-like protein 2, SLITRK2, CXorf2, KIAA1854, SLITL1|
|Target/Specificity||This SLITRK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 773-801 amino acids from the C-terminal region of human SLITRK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLITRK2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CXorf2, KIAA1854, SLITL1|
|Function||It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321). Suppresses neurite outgrowth (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein. Cell membrane|
|Tissue Location||Expressed predominantly in the cerebral cortex of the brain but also at low levels in the spinal cord and medulla. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an integral membrane protein that contains two N-terminal leucine-rich repeats domains and contains C-terminal regions similar to neurotrophin receptors. The encoded protein may play a role in modulating neurite activity. Alternatively spliced transcript variants encoding the same protein have been described.
Piton, A., et al. Mol. Psychiatry (2010) In press :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Smith, E.N., et al. Mol. Psychiatry 14(8):755-763(2009)
Aruga, J., et al. Gene 315, 87-94 (2003) :
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