|Application ||WB, E|
|Calculated MW||58871 Da|
|Antigen Region||172-200 aa|
|Other Names||Probable proline dehydrogenase 2, Kidney and liver proline oxidase 1, HsPOX1, Probable proline oxidase 2, PRODH2|
|Target/Specificity||This PRODH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-200 amino acids from the Central region of human PRODH2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRODH2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone- 10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis- 4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is similar to proline dehydrogenase (oxidase) 1, a mitochondrial enzyme which catalyzes the first step in proline catabolism. The function of this protein has not been determined.
Cooper, S.K., et al. J. Biol. Chem. 283(16):10485-10492(2008)
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