|Application ||WB, E|
|Calculated MW||44836 Da|
|Antigen Region||138-167 aa|
|Other Names||Alpha-2, 8-sialyltransferase 8F, 2499-, Sialyltransferase 8F, SIAT8-F, Sialyltransferase St8Sia VI, ST8SiaVI, ST8SIA6, SIAT8F|
|Target/Specificity||This ST8SIA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-167 amino acids from the Central region of human ST8SIA6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ST8SIA6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc- alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity).|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Sialic acid is a key determinate of oligosaccharide structures involved in cell-cell communication, cell-substrate interaction, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases (EC 22.214.171.124) that synthesize sialylglycoconjugates (Takashima et al., 2002 [PubMed 11980897]).
Yang, J.J., et al. JAMA 301(4):393-403(2009)
Avril, T., et al. J. Leukoc. Biol. 80(4):787-796(2006)
Harduin-Lepers, A., et al. Glycobiology 15(8):805-817(2005)
Deloukas, P., et al. Nature 429(6990):375-381(2004)
Takashima, S., et al. J. Biol. Chem. 277(27):24030-24038(2002)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.