|Application ||WB, E|
|Other Accession||Q8BLG2, NP_005287.1|
|Calculated MW||41895 Da|
|Antigen Region||127-156 aa|
|Other Names||Lysophosphatidic acid receptor 4, LPA receptor 4, LPA-4, G-protein coupled receptor 23, P2Y purinoceptor 9, P2Y9, P2Y5-like receptor, Purinergic receptor 9, LPAR4, GPR23, LPA4, P2RY9|
|Target/Specificity||This LPAR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-156 amino acids from the Central region of human LPAR4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LPAR4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR23, LPA4, P2RY9|
|Function||Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1- alkyl- > 1-alkenyl-LPA.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus and hippocampus.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation.
Liu, Y.B., et al. J. Cell. Biochem. 109(4):794-800(2010)
Kumar, S.A., et al. Leuk. Lymphoma 50(12):2038-2048(2009)
Luttrell, L.M. Mol. Biotechnol. 39(3):239-264(2008)
Dowal, L., et al. J. Biol. Chem. 281(33):23999-24014(2006)
Noguchi, K., et al. J. Biol. Chem. 278(28):25600-25606(2003)
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