|Application ||WB, E|
|Other Accession||Q6I6G8, NP_065811.1|
|Calculated MW||175769 Da|
|Antigen Region||848-876 aa|
|Other Names||E3 ubiquitin-protein ligase HECW2, 632-, HECT, C2 and WW domain-containing protein 2, NEDD4-like E3 ubiquitin-protein ligase 2, HECW2, KIAA1301, NEDL2|
|Target/Specificity||This HECW2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 848-876 amino acids from the Central region of human HECW2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HECW2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, spindle|
|Tissue Location||Predominantly expressed in adult brain, lung and heart.|
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Provided below are standard protocols that you may find useful for product applications.
E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Miyazaki, K., et al. Biochem. Biophys. Res. Commun. 308(1):106-113(2003)
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