|Application ||WB, E|
|Other Accession||NP_079535.4, NP_002432.1|
|Calculated MW||92875 Da|
|Antigen Region||525-552 aa|
|Other Names||MutS protein homolog 5, hMSH5, MSH5|
|Target/Specificity||This MSH5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 525-552 amino acids from the Central region of human MSH5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MSH5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity).|
|Tissue Location||Widely expressed, with high levels in testis and ovary, including granulosa cells (PubMed:9740671, PubMed:28175301). Also expressed in fetal ovary and adrenal gland (PubMed:28175301).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms heterooligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants.
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
Pozo, N.D., et al. Hum. Immunol. 71(9):861-864(2010)
Snowden, T., et al. J. Biol. Chem. 283(1):145-154(2008)
Sekine, H., et al. Proc. Natl. Acad. Sci. U.S.A. 104(17):7193-7198(2007)
Yi, W., et al. Biochem. Biophys. Res. Commun. 332(2):524-532(2005)
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