|Application ||WB, E|
|Calculated MW||32194 Da|
|Antigen Region||247-275 aa|
|Other Names||Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide, hDAPP1, B lymphocyte adapter protein Bam32, B-cell adapter molecule of 32 kDa, DAPP1, BAM32|
|Target/Specificity||This DAPP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-275 amino acids from the C-terminal region of human DAPP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DAPP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a B-cell-associated adapter that regulates B- cell antigen receptor (BCR)-signaling downstream of PI3K.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation|
|Tissue Location||Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
DAPP1 may act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.
Manna, D., et al. J. Biol. Chem. 282(44):32093-32105(2007)
Niiro, H., et al. J. Immunol. 173(9):5601-5609(2004)
Allam, A., et al. J. Biol. Chem. 279(38):39775-39782(2004)
Han, A., et al. Immunity 19(4):621-632(2003)
Marshall, A.J., et al. Mol. Cell. Biol. 22(15):5479-5491(2002)
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