|Application ||WB, E|
|Other Accession||Q8C8U0, NP_003613.2, NP_803193.1|
|Calculated MW||114024 Da|
|Antigen Region||588-617 aa|
|Other Names||Liprin-beta-1, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1, PTPRF-interacting protein-binding protein 1, hSGT2, PPFIBP1, KIAA1230|
|Target/Specificity||This PPFIBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 588-617 amino acids from the Central region of human PPFIBP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PPFIBP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.|
|Tissue Location||Widely expressed. Absent in liver.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Norrmen, C., et al. Blood 115(4):906-909(2010)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Jin, J., et al. Curr. Biol. 14(16):1436-1450(2004)
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