|Application ||WB, E|
|Calculated MW||105114 Da|
|Antigen Region||401-430 aa|
|Other Names||Zinc finger and BTB domain-containing protein 4, KAISO-like zinc finger protein 1, KAISO-L1, ZBTB4, KIAA1538|
|Target/Specificity||This ZBTB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-430 amino acids from the Central region of human ZBTB4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZBTB4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).|
|Cellular Location||Nucleus. Chromosome. Note=Localizes to chromocenters.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
ZBTB4 may be involved in transcriptional regulation.
Sasai, N., et al. Nucleic Acids Res. 38(15):5015-5022(2010)
Yamada, D., et al. Oncogene 28(27):2535-2544(2009)
Weber, A., et al. EMBO J. 27(11):1563-1574(2008)
Filion, G.J., et al. Mol. Cell. Biol. 26(1):169-181(2006)
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