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PDZD3 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PDZD3 Antibody (Center) AP17639c
    PDZD3 Antibody (Center) (Cat. #AP17639c) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the PDZD3 antibody detected the PDZD3 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86UT5
Other Accession NP_001161940.1, NP_079067.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 258-285 aa
Additional Information
Other Names Na(+)/H(+) exchange regulatory cofactor NHE-RF4, NHERF-4, Intestinal and kidney-enriched PDZ protein, Natrium-phosphate cotransporter IIa C-terminal-associated protein 2, Na/Pi cotransporter C-terminal-associated protein 2, NaPi-Cap2, PDZ domain-containing protein 2, PDZ domain-containing protein 3, Sodium-hydrogen exchanger regulatory factor 4, PDZD3, IKEPP, NHERF4, PDZK2
Target/Specificity This PDZD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-285 amino acids from the Central region of human PDZD3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPDZD3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDZD3
Function Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451).
Cellular Location Cell membrane; Peripheral membrane protein Cytoplasm. Note=Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells (PubMed:11950846, PubMed:19088451)
Tissue Location Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin. EMBL; AY047359; AAL10686.1; -; mRNA EMBL; AB094096; BAC76050.1; -; mRNA EMBL; AK026409; BAB15474.1; -; mRNA EMBL; AK091966; BAC03780.1; -; mRNA EMBL; AP002956; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC029042; AAH29042.1; -; mRNA CCDS; CCDS53719.1; -. [Q86UT5-2] CCDS; CCDS8417.1; -. [Q86UT5-3] RefSeq; NP_001161940.1; NM_001168468.1. [Q86UT5-2] RefSeq; NP_079067.3; NM_024791.3. [Q86UT5-3] RefSeq; XP_011541302.1; XM_011543000.2. [Q86UT5-1] RefSeq; XP_011541303.1; XM_011543001.2. [Q86UT5-1] RefSeq; XP_011541304.1; XM_011543002.2. [Q86UT5-1] UniGene; Hs.374726; - PDB; 2V90; X-ray; 2.00 A; A/B/C/D/E/F=326-415 PDBsum; 2V90; - ProteinModelPortal; Q86UT5; - SMR; Q86UT5; - BioGrid; 122940; 8 IntAct; Q86UT5; 6 STRING; 9606.ENSP00000347742; - iPTMnet; Q86UT5; - PhosphoSitePlus; Q86UT5; - BioMuta; PDZD3; - DMDM; 308153467; - MaxQB; Q86UT5; - PaxDb; Q86UT5; - PeptideAtlas; Q86UT5; - PRIDE; Q86UT5; - ProteomicsDB; 69882; - ProteomicsDB; 69883; -. [Q86UT5-2] ProteomicsDB; 69884; -. [Q86UT5-3] ProteomicsDB; 69885; -. [Q86UT5-4] ProteomicsDB; 69886; -. [Q86UT5-5] TopDownProteomics; Q86UT5-4; -. [Q86UT5-4] Ensembl; ENST00000322712; ENSP00000327107; ENSG00000172367. [Q86UT5-3] Ensembl; ENST00000355547; ENSP00000347742; ENSG00000172367. [Q86UT5-2] Ensembl; ENST00000531114; ENSP00000431164; ENSG00000172367. [Q86UT5-1] GeneID; 79849; - KEGG; hsa:79849; - UCSC; uc001pvy.4; human. [Q86UT5-1] CTD; 79849; - DisGeNET; 79849; - EuPathDB; HostDB:ENSG00000172367.15; - GeneCards; PDZD3; - H-InvDB; HIX0201614; - HGNC; HGNC:19891; PDZD3 MIM; 607146; gene neXtProt; NX_Q86UT5; - OpenTargets; ENSG00000172367; - PharmGKB; PA134911718; - eggNOG; ENOG410ITA7; Eukaryota eggNOG; ENOG410XURS; LUCA GeneTree; ENSGT00530000062999; - HOGENOM; HOG000048712; - HOVERGEN; HBG080760; - InParanoid; Q86UT5; - OMA; GVRPRLC; - OrthoDB; EOG091G0KAL; - PhylomeDB; Q86UT5; - TreeFam; TF350449; - Reactome; R-HSA-8942233; Intestinal infectious diseases EvolutionaryTrace; Q86UT5; - GenomeRNAi; 79849; - PRO; PR:Q86UT5; - Proteomes; UP000005640; Chromosome 11 Bgee; ENSG00000172367; - CleanEx; HS_PDZD3; - ExpressionAtlas; Q86UT5; baseline and differential Genevisible; Q86UT5; HS GO; GO:0045177; C:apical part of cell; IDA:UniProtKB GO; GO:0005903; C:brush border; IDA:UniProtKB GO; GO:0005829; C:cytosol; TAS:UniProtKB GO; GO:0035003; C:subapical complex; IDA:UniProtKB GO; GO:0030251; F:guanylate cyclase inhibitor activity; IDA:UniProtKB GO; GO:0008200; F:ion channel inhibitor activity; TAS:UniProtKB GO; GO:0008022; F:protein C-terminus binding; IPI:UniProtKB GO; GO:1990381; F:ubiquitin-specific protease binding; IPI:UniProtKB GO; GO:0006811; P:ion transport; NAS:UniProtKB GO; GO:0010754; P:negative regulation of cGMP-mediated signaling; IDA:UniProtKB GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; IC:UniProtKB GO; GO:0009636; P:response to toxic substance; TAS:UniProtKB GO; GO:0006833; P:water transport; NAS:UniProtKB InterPro; IPR031200; NHERF-4 InterPro; IPR001478; PDZ InterPro; IPR036034; PDZ_sf PANTHER; PTHR14191:SF20; PTHR14191:SF20; 1 Pfam; PF00595; PDZ; 4 SMART; SM00228; PDZ; 4 SUPFAM; SSF50156; SSF50156; 4 PROSITE; PS50106; PDZ; 4 1: Evidence at protein level; 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Membrane; Reference proteome; Repeat CHAIN 1 571 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 /FTId=PRO_0000058292 DOMAIN 115 196 PDZ 1. {ECO:0000255|PROSITE- ProRule:PRU00143} DOMAIN 223 301 PDZ 2. {ECO:0000255|PROSITE- ProRule:PRU00143} DOMAIN 329 412 PDZ 3. {ECO:0000255|PROSITE- ProRule:PRU00143} DOMAIN 467 548 PDZ 4. {ECO:0000255|PROSITE- ProRule:PRU00143} VAR_SEQ 1 66 Missing (in isoform 2, isoform 3 and isoform 5). /FTId=VSP_051786 VAR_SEQ 67 105 TRQKLPSTLSGHRVCQAHGEPVLGLCPLLPLFCCPPHPP -> MEKAADLQDTASLTLKFKFNPKLGIDNPVLSLAEDHDP Y (in isoform 2, isoform 3 and isoform 5). /FTId=VSP_051787 VAR_SEQ 272 285 Missing (in isoform 3) /FTId=VSP_051788 VAR_SEQ 287 571 Missing (in isoform 5) /FTId=VSP_051789 VAR_SEQ 355 386 QFLWEVDPGLPAKKAGMQAGDRLVAVAGESVE -> EWEPW GRWGKVGLGVGTQAYIHLSVHRRGVPV (in isoform 4). /FTId=VSP_051790 VAR_SEQ 387 571 Missing (in isoform 4) /FTId=VSP_051791 CONFLICT 112 112 R -> P (in Ref. 3; BAB15474) CONFLICT 125 125 S -> G (in Ref. 3; BAC03780) CONFLICT 286 286 L -> V (in Ref. 3; BAB15474) CONFLICT 438 438 R -> Q (in Ref. 2; BAC76050 and 5; AAH29042). STRAND 328 333 {ECO:0000244|PDB:2V90} STRAND 341 347 {ECO:0000244|PDB:2V90} STRAND 353 360 {ECO:0000244|PDB:2V90} HELIX 365 368 {ECO:0000244|PDB:2V90} STRAND 375 380 {ECO:0000244|PDB:2V90} HELIX 390 398 {ECO:0000244|PDB:2V90} TURN 399 402 {ECO:0000244|PDB:2V90} STRAND 403 409 {ECO:0000244|PDB:2V90} SEQUENCE 571 AA; 61032 MW; B56CDC91348EE592 CRC64; MVTPSPPGNH SLSLEAPRLH TASDLLGNHS LGLPLITALV GSRDRRGRVF SPVPVPLPTN PTTQHPTRQK LPSTLSGHRV CQAHGEPVLG LCPLLPLFCC PPHPPDPWSL ERPRFCLLSK EEGKSFGFHL QQELGRAGHV VCRVDPGTSA QRQGLQEGDR ILAVNNDVVE HEDYAVVVRR IRASSPRVLL TVLARHAHDV ARAQLGEDAH LCPTLGPGVR PRLCHIVKDE GGFGFSVTHG NQGPFWLVLS TGGAAERAGV PPGARLLEVN GVSVEKFTHN QLTRKLWQSG QQVTLLVAGP EVEEQCRQLG LPLAAPLAEG WALPTKPRCL HLEKGPQGFG FLLREEKGLD GRPGQFLWEV DPGLPAKKAG MQAGDRLVAV AGESVEGLGH EETVSRIQGQ GSCVSLTVVD PEADRFFSMV RLSPLLFLEN TEAPASPRGS SSASLVETED PSLEDTSVPS VPLGSRQCFL YPGPGGSYGF RLSCVASGPR LFISQVTPGG SAARAGLQVG DVILEVNGYP VGGQNDLERL QQLPEAEPPL CLKLAARSLR GLEAWIPPGA AEDWALASDL L
Research Areas
Citations (0)

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Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).


Zachos, N.C., et al. Cell. Physiol. Biochem. 22 (5-6), 693-704 (2008) :
Kato, Y., et al. Mol. Pharmacol. 67(3):734-743(2005)
Hegedus, T., et al. Biochem. Biophys. Res. Commun. 302(3):454-461(2003)
Scott, R.O., et al. J. Biol. Chem. 277(25):22934-22941(2002)

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$ 325.00
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Cat# AP17639c
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