|Application ||WB, E|
|Other Accession||O88520, A6QLV3, NP_031399.2|
|Calculated MW||64888 Da|
|Antigen Region||56-83 aa|
|Other Names||Leucine-rich repeat protein SHOC-2, Protein soc-2 homolog, Protein sur-8 homolog, SHOC2, KIAA0862|
|Target/Specificity||This SHOC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-83 amino acids from the N-terminal region of human SHOC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SHOC2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.|
|Cellular Location||Cytoplasm. Nucleus Note=Translocates from cytoplasm to nucleus upon growth factor stimulation|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair.
Matsunaga-Udagawa, R., et al. J. Biol. Chem. 285(10):7818-7826(2010)
Yoshiki, S., et al. Mol. Biol. Cell 21(6):1088-1096(2010)
Flotho, C., et al. Blood 115 (4), 913 (2010) :
Cordeddu, V., et al. Nat. Genet. 41(9):1022-1026(2009)
Rodriguez-Viciana, P., et al. Mol. Cell 22(2):217-230(2006)
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