|Application ||WB, E|
|Calculated MW||47517 Da|
|Antigen Region||333-362 aa|
|Other Names||Ectonucleoside triphosphate diphosphohydrolase 5, NTPDase 5, CD39 antigen-like 4, ER-UDPase, Guanosine-diphosphatase ENTPD5, GDPase ENTPD5, Nucleoside diphosphatase, Uridine-diphosphatase ENTPD5, UDPase ENTPD5, ENTPD5, CD39L4, PCPH|
|Target/Specificity||This ENTPD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 333-362 amino acids from the C-terminal region of human ENTPD5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ENTPD5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.|
|Cellular Location||Endoplasmic reticulum. Secreted|
|Tissue Location||Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases.
Fransen, K., et al. Hum. Mol. Genet. 19(17):3482-3488(2010)
Villar, J., et al. Cancer Res. 69(1):102-110(2009)
Villar, J., et al. Cancer Res. 67(22):10859-10868(2007)
Regadera, J., et al. Int. J. Oncol. 28(3):595-604(2006)
Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005)
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