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Mouse Lgals3 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Mouse Lgals3 Antibody (Center) AP19314c
    Mouse Lgals3 Antibody (Center)(Cat. #AP19314c) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the Lgals3 antibody detected the Lgals3 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P16110
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 138-167 aa
Additional Information
Other Names Galectin-3, Gal-3, 35 kDa lectin, Carbohydrate-binding protein 35, CBP 35, Galactose-specific lectin 3, IgE-binding protein, L-34 galactoside-binding lectin, Laminin-binding protein, Lectin L-29, Mac-2 antigen, Lgals3
Target/Specificity This Mouse Lgals3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-167 amino acids from the Central region of mouse Lgals3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Lgals3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Lgals3
Function Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.
Cellular Location Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface
Tissue Location The highest levels are found in activated macrophages EMBL; X16834; CAA34736.1; -; mRNA EMBL; J03723; AAA37311.1; -; mRNA EMBL; X16074; CAA34206.1; -; mRNA CCDS; CCDS26986.1; - PIR; S08537; A28651 UniGene; Mm.248615; - ProteinModelPortal; P16110; - SMR; P16110; - DIP; DIP-2152N; - IntAct; P16110; 6 STRING; 10090.ENSMUSP00000114350; - BindingDB; P16110; - ChEMBL; CHEMBL3668; - iPTMnet; P16110; - PhosphoSitePlus; P16110; - SwissPalm; P16110; - EPD; P16110; - jPOST; P16110; - MaxQB; P16110; - PaxDb; P16110; - PeptideAtlas; P16110; - PRIDE; P16110; - MGI; MGI:96778; Lgals3 eggNOG; KOG3587; Eukaryota eggNOG; ENOG4111EA0; LUCA HOGENOM; HOG000246423; - HOVERGEN; HBG006255; - InParanoid; P16110; - ChiTaRS; Lgals3; mouse PRO; PR:P16110; - Proteomes; UP000000589; Unplaced GO; GO:0009986; C:cell surface; IDA:CACAO GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL GO; GO:0005737; C:cytoplasm; IDA:MGI GO; GO:0009897; C:external side of plasma membrane; IDA:MGI GO; GO:0031012; C:extracellular matrix; IDA:MGI GO; GO:0005576; C:extracellular region; TAS:Reactome GO; GO:0005615; C:extracellular space; HDA:BHF-UCL GO; GO:0097386; C:glial cell projection; IDA:MGI GO; GO:0001772; C:immunological synapse; IDA:BHF-UCL GO; GO:0005743; C:mitochondrial inner membrane; ISO:MGI GO; GO:0005634; C:nucleus; IDA:MGI GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW GO; GO:0050785; F:advanced glycation end-product receptor activity; ISO:MGI GO; GO:0042056; F:chemoattractant activity; ISO:MGI GO; GO:0048030; F:disaccharide binding; ISO:MGI GO; GO:0034988; F:Fc-gamma receptor I complex binding; ISO:MGI GO; GO:0019863; F:IgE binding; ISO:MGI GO; GO:0043236; F:laminin binding; ISO:MGI GO; GO:0048029; F:monosaccharide binding; ISO:MGI GO; GO:0019903; F:protein phosphatase binding; ISO:MGI GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW GO; GO:0048245; P:eosinophil chemotaxis; ISO:MGI GO; GO:0030198; P:extracellular matrix organization; IGI:MGI GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW GO; GO:0048246; P:macrophage chemotaxis; ISO:MGI GO; GO:0002548; P:monocyte chemotaxis; ISO:MGI GO; GO:0071674; P:mononuclear cell migration; ISO:MGI GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI GO; GO:1903769; P:negative regulation of cell proliferation in bone marrow; ISO:MGI GO; GO:0045806; P:negative regulation of endocytosis; IMP:BHF-UCL GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; ISO:MGI GO; GO:2000521; P:negative regulation of immunological synapse formation; IMP:BHF-UCL GO; GO:2001189; P:negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; IMP:BHF-UCL GO; GO:0050860; P:negative regulation of T cell receptor signaling pathway; IMP:BHF-UCL GO; GO:0030593; P:neutrophil chemotaxis; ISO:MGI GO; GO:0050918; P:positive chemotaxis; ISO:MGI GO; GO:0045766; P:positive regulation of angiogenesis; ISO:MGI GO; GO:0090280; P:positive regulation of calcium ion import; ISO:MGI GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI GO; GO:0071677; P:positive regulation of mononuclear cell migration; ISO:MGI GO; GO:0090073; P:positive regulation of protein homodimerization activity; ISO:MGI GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; ISO:MGI GO; GO:0014064; P:positive regulation of serotonin secretion; ISO:MGI GO; GO:1902041; P:regulation of extrinsic apoptotic signaling pathway via death domain receptors; ISO:MGI GO; GO:0070232; P:regulation of T cell apoptotic process; ISO:MGI GO; GO:0042129; P:regulation of T cell proliferation; ISO:MGI GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW GO; GO:0001501; P:skeletal system development; IGI:MGI CDD; cd00070; GLECT; 1 InterPro; IPR013320; ConA-like_dom_sf InterPro; IPR015534; Galectin_3 InterPro; IPR001079; Galectin_CRD PANTHER; PTHR11346:SF26; PTHR11346:SF26; 1 Pfam; PF00337; Gal-bind_lectin; 1 SMART; SM00908; Gal-bind_lectin; 1 SMART; SM00276; GLECT; 1 SUPFAM; SSF49899; SSF49899; 1 PROSITE; PS51304; GALECTIN; 1 1: Evidence at protein level; Acetylation; Complete proteome; Cytoplasm; Differentiation; Direct protein sequencing; Disulfide bond; IgE-binding protein; Immunity; Innate immunity; Lectin; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Secreted; Spliceosome INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:P38486} CHAIN 2 264 Galectin-3 /FTId=PRO_0000076931 REPEAT 35 43 1 REPEAT 44 52 2 REPEAT 53 61 3 REPEAT 62 70 4 REPEAT 71 79 5 REPEAT 80 88 6 REPEAT 89 97 7 REPEAT 98 107 8 REPEAT 108 114 9; truncated DOMAIN 132 262 Galectin. {ECO:0000255|PROSITE- ProRule:PRU00639} REGION 35 114 9 X 9 AA tandem repeats of Y-P-G-X(3)-P- [GS]-A REGION 195 201 Beta-galactoside binding. MOTIF 240 255 Nuclear export signal MOD_RES 2 2 N-acetylalanine {ECO:0000250|UniProtKB:P38486} MOD_RES 6 6 Phosphoserine; by CK1 {ECO:0000250|UniProtKB:P38486} MOD_RES 202 202 Phosphoserine {ECO:0000250|UniProtKB:P17931} DISULFID 187 187 Interchain. CONFLICT 2 2 A -> R (in Ref. 2; AAA37311) CONFLICT 4 4 S -> T (in Ref. 3; CAA34206) CONFLICT 92 93 QP -> ST (in Ref. 3; CAA34206) CONFLICT 110 112 QCS -> SAP (in Ref. 3; CAA34206) CONFLICT 252 252 G -> R (in Ref. 2; AAA37311) SEQUENCE 264 AA; 27515 MW; 1B5A8A81093D68F6 CRC64; MADSFSLNDA LAGSGNPNPQ GYPGAWGNQP GAGGYPGAAY PGAYPGQAPP GAYPGQAPPG AYPGQAPPSA YPGPTAPGAY PGPTAPGAYP GQPAPGAFPG QPGAPGAYPQ CSGGYPAAGP YGVPAGPLTV PYDLPLPGGV MPRMLITIMG TVKPNANRIV LDFRRGNDVA FHFNPRFNEN NRRVIVCNTK QDNNWGKEER QSAFPFESGK PFKIQVLVEA DHFKVAVNDA HLLQYNHRMK NLREISQLGI SGDITLTSAN HAMI
Research Areas
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Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity).

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$ 325.00
$ 109.00
Cat# AP19314c
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