|Application ||WB, E|
|Other Accession||Q9D7J7, NP_115706.1|
|Calculated MW||27660 Da|
|Antigen Region||55-83 aa|
|Other Names||Calpain small subunit 2, CSS2, Calcium-dependent protease small subunit 2, CAPNS2|
|Target/Specificity||This CAPNS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the Central region of human CAPNS2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CAPNS2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity.|
|Cellular Location||Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon calcium binding.|
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Provided below are standard protocols that you may find useful for product applications.
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Ma, H., et al. Curr. Eye Res. 29 (4-5), 337-347 (2004) :
Schad, E., et al. Biochem. J. 362 (PT 2), 383-388 (2002) :
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