|Application ||WB, E|
|Calculated MW||87428 Da|
|Antigen Region||283-310 aa|
|Other Names||PAS domain-containing protein 1, Cancer/testis antigen 63, CT63, OX-TES-1, PASD1|
|Target/Specificity||This PASD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-310 amino acids from the Central region of human PASD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PASD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801). Acts as a nuclear repressor of the CLOCK- ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801). Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801).|
|Cellular Location||Isoform 1: Nucleus. Note=Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801).|
|Tissue Location||Testis-specific (PubMed:25936801). Expressed in a broad range of cancer cells, including melanoma, lung cancer, and breast cancer (at protein level). Testis-specific (PubMed:15162151). Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widespread expression seen in solid tumors and diffuse large B-cell lymphoma (DLBCL)-derived cell lines. Isoform 2 is expressed in all DLBCL- derived cell lines, while isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL (PubMed:15162151).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is thought to function as a transcription factor. The protein is a cancer-associated antigen that can stimulate autologous T-cell responses, and it is therefore considered to be a potential immunotherapeutic target for the treatment of various hematopoietic malignancies, including diffuse large B-cell lymphoma.
Ghafouri-Fard, S., et al. Br. J. Dermatol. 162(4):772-779(2010)
Ait-Tahar, K., et al. Br. J. Haematol. 146(4):396-407(2009)
Sahota, S.S., et al. Blood 108(12):3953-3955(2006)
Cooper, C.D., et al. Leukemia 20(12):2172-2174(2006)
Guinn, B.A., et al. Biochem. Biophys. Res. Commun. 335(4):1293-1304(2005)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.