|Application ||WB, E|
|Other Accession||Q5M7T3, Q99N20, NP_056214.1|
|Calculated MW||28461 Da|
|Antigen Region||48-77 aa|
|Other Names||Breast cancer metastasis-suppressor 1, BRMS1|
|Target/Specificity||This BRMS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-77 amino acids from the N-terminal region of human BRMS1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BRMS1 Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.|
|Cellular Location||Nucleus. Cytoplasm. Note=Predominantly nuclear|
|Tissue Location||Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies|
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Provided below are standard protocols that you may find useful for product applications.
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.
Wu, Y., et al. Cancer Lett. 293(1):82-91(2010)
Vaidya, K.S., et al. Cancer Lett. 281(1):100-107(2009)
Frolova, N., et al. Tumour Biol. 30(3):148-159(2009)
Martins-de-Souza, D., et al. BMC Psychiatry 9, 17 (2009) :
Cicek, M., et al. Clin. Exp. Metastasis 26(3):229-237(2009)
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