|Application ||WB, E|
|Other Accession||B0BN18, O70591, A1A4P5, NP_036526.2|
|Calculated MW||16648 Da|
|Antigen Region||97-125 aa|
|Other Names||Prefoldin subunit 2, PFDN2, PFD2|
|Target/Specificity||This PFDN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-125 amino acids from the C-terminal region of human PFDN2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PFDN2 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|
|Cellular Location||Nucleus. Cytoplasm. Mitochondrion|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.
Cloutier, P., et al. Methods 48(4):381-386(2009) Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) : Simons, C.T., et al. J. Biol. Chem. 279(6):4196-4203(2004) Bouwmeester, T., et al. Nat. Cell Biol. 6(2):97-105(2004) Hu, R.M., et al. Proc. Natl. Acad. Sci. U.S.A. 97(17):9543-9548(2000)
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