|Application ||WB, E|
|Other Accession||Q8CHK3, Q0VCY6, NP_001139528.1, NP_001139554.1, NP_001139555.1, NP_077274.3|
|Calculated MW||52765 Da|
|Antigen Region||151-180 aa|
|Other Names||Lysophospholipid acyltransferase 7, LPLAT 7, 231-, 1-acylglycerophosphatidylinositol O-acyltransferase, 231n4, Bladder and breast carcinoma-overexpressed gene 1 protein, Leukocyte receptor cluster member 4, Lysophosphatidylinositol acyltransferase, LPIAT, Lyso-PI acyltransferase, Membrane-bound O-acyltransferase domain-containing protein 7, O-acyltransferase domain-containing protein 7, h-mboa-7, MBOAT7, BB1, LENG4, OACT7|
|Target/Specificity||This MBOAT7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from the Central region of human MBOAT7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MBOAT7 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BB1, LENG4, OACT7|
|Function||Acyltransferase which contributes to the regulation of free arachidonic acid (AA) in the cell through the remodeling of phospholipids. Mediates the conversion of lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Required for cortical lamination during brain development (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localized in specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria|
|Tissue Location||Overexpressed in metastatic breast and bladder carcinomas relative to normal breast epithelium and urothelium|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the membrane-bound O-acyltransferases family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the reacylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle. Alternative splicing results in multiple transcript variants.
Gijon, M.A., et al. J. Biol. Chem. 283(44):30235-30245(2008)
Lee, H.C., et al. Mol. Biol. Cell 19(3):1174-1184(2008)
Wende, H., et al. Immunogenetics 51 (8-9), 703-713 (2000) :
Fukunaga-Johnson, N., et al. Anticancer Res. 16 (3A), 1085-1090 (1996) :
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