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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   IL17RE Antibody(N-term)   

IL17RE Antibody(N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - IL17RE Antibody(N-term) AP19700a
    IL17RE Antibody (N-term) (Cat. #AP19700a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the IL17RE antibody detected the IL17RE protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8NFR9
Other Accession NP_001180309.1, NP_705613.1, NP_705616.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 87-116 aa
Additional Information
Other Names Interleukin-17 receptor E, IL-17 receptor E, IL-17RE, IL17RE
Target/Specificity This IL17RE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-116 amino acids from the N-terminal region of human IL17RE.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIL17RE Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL17RE
Function Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted. Isoform 5: Secreted.
Tissue Location Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines. EMBL; AF458069; AAM77573.1; -; mRNA EMBL; AY358451; AAQ88816.1; -; mRNA EMBL; AK074238; BAB85028.1; ALT_FRAME; mRNA EMBL; AK096793; BAC04863.1; -; mRNA EMBL; AK096801; BAC04864.1; -; mRNA EMBL; AK314476; BAG37081.1; -; mRNA EMBL; CH471055; EAW64019.1; -; Genomic_DNA EMBL; CH471055; EAW64020.1; -; Genomic_DNA EMBL; CH471055; EAW64016.1; -; Genomic_DNA EMBL; BC063110; AAH63110.1; -; mRNA EMBL; BC137077; AAI37078.1; -; mRNA EMBL; BC137078; AAI37079.1; -; mRNA CCDS; CCDS2589.1; -. [Q8NFR9-1] CCDS; CCDS54552.1; -. [Q8NFR9-3] RefSeq; NP_001180309.1; NM_001193380.1. [Q8NFR9-3] RefSeq; NP_705613.1; NM_153480.1. [Q8NFR9-1] RefSeq; NP_705614.1; NM_153481.1. [Q8NFR9-2] RefSeq; NP_705616.2; NM_153483.2 RefSeq; XP_006713039.1; XM_006712976.1. [Q8NFR9-2] UniGene; Hs.390823; - ProteinModelPortal; Q8NFR9; - SMR; Q8NFR9; - BioGrid; 126304; 12 IntAct; Q8NFR9; 1 STRING; 9606.ENSP00000295980; - iPTMnet; Q8NFR9; - PhosphoSitePlus; Q8NFR9; - BioMuta; IL17RE; - DMDM; 74730297; - PaxDb; Q8NFR9; - PeptideAtlas; Q8NFR9; - PRIDE; Q8NFR9; - ProteomicsDB; 73342; - ProteomicsDB; 73343; -. [Q8NFR9-2] ProteomicsDB; 73344; -. [Q8NFR9-3] ProteomicsDB; 73345; -. [Q8NFR9-4] ProteomicsDB; 73346; -. [Q8NFR9-5] Ensembl; ENST00000383814; ENSP00000373325; ENSG00000163701. [Q8NFR9-1] Ensembl; ENST00000454190; ENSP00000388086; ENSG00000163701. [Q8NFR9-3] GeneID; 132014; - KEGG; hsa:132014; - UCSC; uc003btw.4; human. [Q8NFR9-1] CTD; 132014; - DisGeNET; 132014; - EuPathDB; HostDB:ENSG00000163701.18; - GeneCards; IL17RE; - HGNC; HGNC:18439; IL17RE HPA; HPA019011; - MIM; 614995; gene neXtProt; NX_Q8NFR9; - OpenTargets; ENSG00000163701; - PharmGKB; PA134896136; - eggNOG; ENOG410IFAR; Eukaryota eggNOG; ENOG410XTAY; LUCA GeneTree; ENSGT00730000111008; - HOVERGEN; HBG102913; - InParanoid; Q8NFR9; - KO; K05168; - PhylomeDB; Q8NFR9; - TreeFam; TF335690; - Reactome; R-HSA-448424; Interleukin-17 signaling GenomeRNAi; 132014; - PRO; PR:Q8NFR9; - Proteomes; UP000005640; Chromosome 3 Bgee; ENSG00000163701; - CleanEx; HS_IL17RE; - ExpressionAtlas; Q8NFR9; baseline and differential Genevisible; Q8NFR9; HS GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central GO; GO:0005886; C:plasma membrane; TAS:Reactome GO; GO:0030368; F:interleukin-17 receptor activity; IBA:GO_Central GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW GO; GO:0097400; P:interleukin-17-mediated signaling pathway; TAS:Reactome InterPro; IPR027841; IL-17_rcpt_C/E_N InterPro; IPR013568; SEFIR_dom Pfam; PF15037; IL17_R_N; 1 Pfam; PF08357; SEFIR; 2 PROSITE; PS51534; SEFIR; 1 1: Evidence at protein level; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Glycoprotein; Inflammatory response; Membrane; Polymorphism; Receptor; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix SIGNAL 1 23 CHAIN 24 667 Interleukin-17 receptor E /FTId=PRO_0000309467 TOPO_DOM 24 454 Extracellular. TRANSMEM 455 475 Helical. TOPO_DOM 476 667 Cytoplasmic. DOMAIN 487 624 SEFIR. {ECO:0000255|PROSITE- ProRule:PRU00867} CARBOHYD 318 318 N-linked (GlcNAc...) asparagine CARBOHYD 347 347 N-linked (GlcNAc...) asparagine CARBOHYD 364 364 N-linked (GlcNAc...) asparagine VAR_SEQ 1 116 Missing (in isoform 2 and isoform 4) /FTId=VSP_029190 VAR_SEQ 268 271 YGSD -> CECC (in isoform 5) /FTId=VSP_029191 VAR_SEQ 272 667 Missing (in isoform 5) /FTId=VSP_029192 VAR_SEQ 433 533 VWRSDVQFAWKHLLCPDVSYRHLGLLILALLALLTLLGVVL ALTCRRPQSGPGPARPVLLLHAADSEAQRRLVGALAELLRA ALGGGRDVIVDLWEGRHVA -> LHASLSSPGGEDAWLIGV GGSVPSGVAVRCPVCLEAPLVSGCLLQTPGALDPGTAGPPH PTGCCSGPHLPAPTVRPGPSAASAPPARGGLGGAAAPGGSA G (in isoform 3) /FTId=VSP_029193 VAR_SEQ 433 506 VWRSDVQFAWKHLLCPDVSYRHLGLLILALLALLTLLGVVL ALTCRRPQSGPGPARPVLLLHAADSEAQRRLVG -> ASSW SRHKPTWEEFPSQWGLPSPPAPCFTQLPGRRRCLAHRGGGL CALRCGGQMSSLPGSTSCVRMSLTDTWGS (in isoform 4). /FTId=VSP_029194 VAR_SEQ 507 667 Missing (in isoform 4) /FTId=VSP_029195 VAR_SEQ 534 667 Missing (in isoform 3) /FTId=VSP_029196 VARIANT 219 219 Y -> C (in dbSNP:rs7356031) /FTId=VAR_036956 VARIANT 402 402 P -> S (in dbSNP:rs9870003) /FTId=VAR_036957 VARIANT 417 417 S -> T (in dbSNP:rs7647642) /FTId=VAR_036958 CONFLICT 270 270 S -> P (in Ref. 3; BAC04864) CONFLICT 445 445 L -> F (in Ref. 3; BAC04864) SEQUENCE 667 AA; 74810 MW; 1493744E7354067D CRC64; MGSSRLAALL LPLLLIVIDL SDSAGIGFRH LPHWNTRCPL ASHTDDSFTG SSAYIPCRTW WALFSTKPWC VRVWHCSRCL CQHLLSGGSG LQRGLFHLLV QKSKKSSTFK FYRRHKMPAP AQRKLLPRRH LSEKSHHISI PSPDISHKGL RSKRTQPSDP ETWESLPRLD SQRHGGPEFS FDLLPEARAI RVTISSGPEV SVRLCHQWAL ECEELSSPYD VQKIVSGGHT VELPYEFLLP CLCIEASYLQ EDTVRRKKCP FQSWPEAYGS DFWKSVHFTD YSQHTQMVMA LTLRCPLKLE AALCQRHDWH TLCKDLPNAT ARESDGWYVL EKVDLHPQLC FKFSFGNSSH VECPHQTGSL TSWNVSMDTQ AQQLILHFSS RMHATFSAAW SLPGLGQDTL VPPVYTVSQA RGSSPVSLDL IIPFLRPGCC VLVWRSDVQF AWKHLLCPDV SYRHLGLLIL ALLALLTLLG VVLALTCRRP QSGPGPARPV LLLHAADSEA QRRLVGALAE LLRAALGGGR DVIVDLWEGR HVARVGPLPW LWAARTRVAR EQGTVLLLWS GADLRPVSGP DPRAAPLLAL LHAAPRPLLL LAYFSRLCAK GDIPPPLRAL PRYRLLRDLP RLLRALDARP FAEATSWGRL GARQRRQSRL ELCSRLEREA ARLADLG
Research Areas
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This gene encodes a protein that shares limited similarity with the interleukin-17 receptor. The function of the encoded protein has not yet been determined. Alternatively spliced transcript variants have been described.


Eid, N.A., et al. Malar. J. 9, 119 (2010) :
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)

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$ 325.00
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Cat# AP19700a
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