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LGALS3BP Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - LGALS3BP Antibody (Center) AP19780c
    All lanes : Anti-LGALS3BP Antibody (Center) at 1:2000 dilution Lane 1: Human liver tissue lysate Lane 2: Mouse lung tissue lysate Lane 3: Human plasma tissue lysate Lane 4: NIH/3T3 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 65 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - LGALS3BP Antibody (Center) AP19780c
    All lanes : Anti-LGALS3BP Antibody (Center) at 1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: Human plasma lysate Lane 3: Mouse lung lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 65 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q08380
Other Accession NP_005558.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 383-412 aa
Additional Information
Other Names Galectin-3-binding protein, Basement membrane autoantigen p105, Lectin galactoside-binding soluble 3-binding protein, Mac-2-binding protein, MAC2BP, Mac-2 BP, Tumor-associated antigen 90K, LGALS3BP, M2BP
Target/Specificity This LGALS3BP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-412 amino acids from the Central region of human LGALS3BP.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLGALS3BP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms M2BP
Function Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
Cellular Location Secreted. Secreted, extracellular space, extracellular matrix
Tissue Location Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts. EMBL; L13210; AAA36193.1; -; mRNA EMBL; X79089; CAA55699.1; -; mRNA EMBL; BC002403; AAH02403.1; -; mRNA EMBL; BC002998; AAH02998.1; -; mRNA EMBL; BC015761; AAH15761.1; -; mRNA CCDS; CCDS11759.1; - PIR; A47161; A47161 PIR; A55899; A55899 RefSeq; NP_005558.1; NM_005567.3 UniGene; Hs.514535; - PDB; 1BY2; X-ray; 2.00 A; A=19-133 PDB; 6GFB; X-ray; 2.08 A; A/B=124-250 PDBsum; 1BY2; - PDBsum; 6GFB; - ProteinModelPortal; Q08380; - SMR; Q08380; - BioGrid; 110150; 185 IntAct; Q08380; 74 MINT; Q08380; - STRING; 9606.ENSP00000262776; - GlyConnect; 1256; - iPTMnet; Q08380; - PhosphoSitePlus; Q08380; - SwissPalm; Q08380; - BioMuta; LGALS3BP; - DMDM; 47115668; - EPD; Q08380; - jPOST; Q08380; - MaxQB; Q08380; - PaxDb; Q08380; - PeptideAtlas; Q08380; - PRIDE; Q08380; - ProteomicsDB; 58606; - DNASU; 3959; - Ensembl; ENST00000262776; ENSP00000262776; ENSG00000108679 GeneID; 3959; - KEGG; hsa:3959; - UCSC; uc002jwh.4; human CTD; 3959; - DisGeNET; 3959; - EuPathDB; HostDB:ENSG00000108679.12; - GeneCards; LGALS3BP; - HGNC; HGNC:6564; LGALS3BP HPA; CAB002158; - HPA; HPA000554; - MIM; 600626; gene neXtProt; NX_Q08380; - OpenTargets; ENSG00000108679; - PharmGKB; PA30341; - eggNOG; ENOG410IY2Y; Eukaryota eggNOG; ENOG410YBYF; LUCA GeneTree; ENSGT00940000162516; - HOGENOM; HOG000113318; - HOVERGEN; HBG052323; - InParanoid; Q08380; - KO; K17300; - OMA; IGYENKA; - OrthoDB; 1174057at2759; - PhylomeDB; Q08380; - TreeFam; TF331368; - Reactome; R-HSA-114608; Platelet degranulation SIGNOR; Q08380; - ChiTaRS; LGALS3BP; human EvolutionaryTrace; Q08380; - GeneWiki; LGALS3BP; - GenomeRNAi; 3959; - PMAP-CutDB; Q08380; - PRO; PR:Q08380; - Proteomes; UP000005640; Chromosome 17 Bgee; ENSG00000108679; Expressed in 221 organ(s), highest expression level in heart left ventricle ExpressionAtlas; Q08380; baseline and differential Genevisible; Q08380; HS GO; GO:0072562; C:blood microparticle; HDA:UniProtKB GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB GO; GO:0005576; C:extracellular region; HDA:BHF-UCL GO; GO:0005615; C:extracellular space; IDA:UniProtKB GO; GO:0016020; C:membrane; IEA:InterPro GO; GO:0031089; C:platelet dense granule lumen; TAS:Reactome GO; GO:0005044; F:scavenger receptor activity; TAS:ProtInc GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW GO; GO:0006968; P:cellular defense response; TAS:ProtInc GO; GO:0002576; P:platelet degranulation; TAS:Reactome GO; GO:0007165; P:signal transduction; TAS:ProtInc Gene3D;; -; 1 InterPro; IPR011705; BACK InterPro; IPR000210; BTB/POZ_dom InterPro; IPR001190; SRCR InterPro; IPR017448; SRCR-like_dom InterPro; IPR036772; SRCR-like_dom_sf Pfam; PF07707; BACK; 1 Pfam; PF00530; SRCR; 1 PRINTS; PR00258; SPERACTRCPTR SMART; SM00875; BACK; 1 SMART; SM00202; SR; 1 SUPFAM; SSF56487; SSF56487; 1 PROSITE; PS50097; BTB; 1 PROSITE; PS00420; SRCR_1; 1 PROSITE; PS50287; SRCR_2; 1 1: Evidence at protein level; 3D-structure; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Extracellular matrix; Glycoprotein; Reference proteome; Secreted; Signal SIGNAL 1 18 CHAIN 19 585 Galectin-3-binding protein /FTId=PRO_0000033230 DOMAIN 24 124 SRCR. {ECO:0000255|PROSITE- ProRule:PRU00196} DOMAIN 153 221 BTB. {ECO:0000255|PROSITE- ProRule:PRU00037} DOMAIN 260 360 BACK CARBOHYD 69 69 N-linked (GlcNAc...) (complex) asparagine. CARBOHYD 125 125 N-linked (GlcNAc...) asparagine CARBOHYD 192 192 N-linked (GlcNAc...) asparagine CARBOHYD 362 362 N-linked (GlcNAc...) asparagine CARBOHYD 398 398 N-linked (GlcNAc...) (complex) asparagine. CARBOHYD 551 551 N-linked (GlcNAc...) (complex) asparagine. CARBOHYD 580 580 N-linked (GlcNAc...) (complex) asparagine. DISULFID 49 113 {ECO:0000244|PDB:1BY2, ECO:0000269|PubMed:9501082} DISULFID 62 123 {ECO:0000244|PDB:1BY2, ECO:0000269|PubMed:9501082} DISULFID 93 103 {ECO:0000244|PDB:1BY2, ECO:0000269|PubMed:9501082} CONFLICT 19 19 V -> S (in Ref. 5; AA sequence) CONFLICT 25 25 R -> C (in Ref. 4; AA sequence) CONFLICT 25 25 R -> P (in Ref. 4; AA sequence) CONFLICT 26 26 L -> M (in Ref. 5; AA sequence) CONFLICT 30 31 GA -> ED (in Ref. 5; AA sequence) CONFLICT 36 36 R -> H (in Ref. 5; AA sequence) CONFLICT 36 36 R -> L (in Ref. 4; AA sequence) STRAND 24 28 {ECO:0000244|PDB:1BY2} STRAND 34 41 {ECO:0000244|PDB:1BY2} STRAND 44 49 {ECO:0000244|PDB:1BY2} HELIX 55 64 {ECO:0000244|PDB:1BY2} STRAND 70 74 {ECO:0000244|PDB:1BY2} TURN 76 79 {ECO:0000244|PDB:1BY2} STRAND 86 88 {ECO:0000244|PDB:1BY2} HELIX 100 102 {ECO:0000244|PDB:1BY2} HELIX 115 117 {ECO:0000244|PDB:1BY2} STRAND 120 123 {ECO:0000244|PDB:1BY2} STRAND 131 134 {ECO:0000244|PDB:6GFB} HELIX 136 138 {ECO:0000244|PDB:6GFB} HELIX 139 149 {ECO:0000244|PDB:6GFB} STRAND 155 161 {ECO:0000244|PDB:6GFB} STRAND 164 171 {ECO:0000244|PDB:6GFB} HELIX 173 176 {ECO:0000244|PDB:6GFB} HELIX 180 185 {ECO:0000244|PDB:6GFB} STRAND 191 196 {ECO:0000244|PDB:6GFB} HELIX 199 204 {ECO:0000244|PDB:6GFB} HELIX 205 214 {ECO:0000244|PDB:6GFB} STRAND 215 219 {ECO:0000244|PDB:6GFB} TURN 221 223 {ECO:0000244|PDB:6GFB} HELIX 224 234 {ECO:0000244|PDB:6GFB} HELIX 237 246 {ECO:0000244|PDB:6GFB} SEQUENCE 585 AA; 65331 MW; C488C2E99D77435B CRC64; MTPPRLFWVW LLVAGTQGVN DGDMRLADGG ATNQGRVEIF YRGQWGTVCD NLWDLTDASV VCRALGFENA TQALGRAAFG QGSGPIMLDE VQCTGTEASL ADCKSLGWLK SNCRHERDAG VVCTNETRST HTLDLSRELS EALGQIFDSQ RGCDLSISVN VQGEDALGFC GHTVILTANL EAQALWKEPG SNVTMSVDAE CVPMVRDLLR YFYSRRIDIT LSSVKCFHKL ASAYGARQLQ GYCASLFAIL LPQDPSFQMP LDLYAYAVAT GDALLEKLCL QFLAWNFEAL TQAEAWPSVP TDLLQLLLPR SDLAVPSELA LLKAVDTWSW GERASHEEVE GLVEKIRFPM MLPEELFELQ FNLSLYWSHE ALFQKKTLQA LEFHTVPFQL LARYKGLNLT EDTYKPRIYT SPTWSAFVTD SSWSARKSQL VYQSRRGPLV KYSSDYFQAP SDYRYYPYQS FQTPQHPSFL FQDKRVSWSL VYLPTIQSCW NYGFSCSSDE LPVLGLTKSG GSDRTIAYEN KALMLCEGLF VADVTDFEGW KAAIPSALDT NSSKSTSSFP CPAGHFNGFR TVIRPFYLTN SSGVD
Research Areas
Citations (0)

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The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1.


Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Srirajaskanthan, R., et al. Mol. Cell Proteomics 9(4):656-666(2010)
Zambelli, D., et al. Int. J. Cancer 126(1):41-52(2010)
Lee, J.H., et al. Pathology 41(3):229-233(2009)
Kim, S.J., et al. Acta Haematol. 120(4):211-216(2008)

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Cat# AP19780c
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