|Application ||WB, E|
|Calculated MW||92416 Da|
|Antigen Region||818-846 aa|
|Other Names||Cadherin-like protein 26, Cadherin-like protein VR20, CDH26|
|Target/Specificity||This CDH26 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 818-846 amino acids from the C-terminal region of human CDH26.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CDH26 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Ligand for integrins alpha- E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha- 4/beta-1, ITGA4:ITGAB1 through which modulates CD4(+) T cells activation (PubMed:28051089).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed by epithelial cells of gastrointestinal tissue.|
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Provided below are standard protocols that you may find useful for product applications.
Cadherins are a family of adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in all solid tissues and modulate a wide variety of processes, including cell polarization and migration. Cadherin domains occur as repeats in the extracellular region and are thought to contribute to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. This gene encodes a cadherin domain-containing protein whose specific function has not yet been determined. Alternative splicing occurs at this locus and two transcript variants, encoding distinct proteins, have been identified.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Ferreira, M.A., et al. Allergy 64(11):1623-1628(2009)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000)
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