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EFNB1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - EFNB1 Antibody (Center) AP20103c
    EFNB1 Antibody (Center) (Cat. #AP20103c) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the EFNB1 antibody detected the EFNB1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P98172
Other Accession O73612, NP_004420.1
Reactivity Human
Predicted Chicken
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 38007 Da
Antigen Region 88-116 aa
Additional Information
Gene ID 1947
Other Names Ephrin-B1, EFL-3, ELK ligand, ELK-L, EPH-related receptor tyrosine kinase ligand 2, LERK-2, EFNB1, EFL3, EPLG2, LERK2
Target/Specificity This EFNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-116 amino acids from the Central region of human EFNB1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEFNB1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EFNB1
Synonyms EFL3, EPLG2, LERK2
Function Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:8070404, PubMed:7973638). Binding to Eph receptors residing on adjacent cells leads to contact- dependent bidirectional signaling into neighboring cells (PubMed:8070404, PubMed:7973638). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:8070404, PubMed:7973638). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein. Membrane raft Note=May recruit GRIP1 and GRIP2 to membrane raft domains Ephrin-B1 intracellular domain: Nucleus. Note=Colocalizes with ZHX2 in the nucleus. {ECO:0000250|UniProtKB:P52795}
Tissue Location Widely expressed (PubMed:8070404, PubMed:7973638). Detected in both neuronal and non-neuronal tissues (PubMed:8070404, PubMed:7973638). Seems to have particularly strong expression in retina, sciatic nerve, heart and spinal cord (PubMed:7973638).
Research Areas
Citations (0)

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Background

The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system.

References

Hogue, J., et al. Am. J. Med. Genet. A 152A (10), 2574-2577 (2010) :
Arvanitis, D.N., et al. Mol. Cell. Biol. 30(10):2508-2517(2010)
Makarov, R., et al. BMC Med. Genet. 11, 98 (2010) :
Vazin, T., et al. PLoS ONE 4 (8), E6606 (2009) :
Wallis, D., et al. Am. J. Med. Genet. A 146A (15), 2008-2012 (2008) :

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$ 325.00
$ 109.00
Cat# AP20103c
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