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>   home   >   Products   >   Primary Antibodies   >   Cardiovascular   >   XLKD1 Antibody (N-term)   

XLKD1 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - XLKD1 Antibody (N-term) AP2015a
    Anti-XLKD1 Antibody (N-term) at 1:2000 dilution + human liver lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 35 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - XLKD1 Antibody (N-term) AP2015a
    The anti-XLKD1 N-term Pab (Cat. #AP2015a) is used in Western blot to detect XLKD1 in mouse liver tissue lysate.
  • IHC-P - XLKD1 Antibody (N-term) AP2015a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
  • WB - XLKD1 Antibody (N-term) AP2015a
    XLKD1 Antibody (N-term) (Cat. #AP2015a) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the XLKD1 antibody detected the XLKD1 protein (arrow).
  • WB - XLKD1 Antibody (N-term) AP2015a
    Western blot analysis of XLKD1 (arrow) using rabbit polyclonal XLKD1 Antibody (C61) (Cat. #AP2015a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the XLKD1 gene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y5Y7
Other Accession NP_006682
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 35213 Da
Antigen Region 46-77 aa
Additional Information
Gene ID 10894
Other Names Lymphatic vessel endothelial hyaluronic acid receptor 1, LYVE-1, Cell surface retention sequence-binding protein 1, CRSBP-1, Extracellular link domain-containing protein 1, Hyaluronic acid receptor, LYVE1, CRSBP1, HAR, XLKD1
Target/Specificity This XLKD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-77 amino acids from the N-terminal region of human XLKD1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsXLKD1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LYVE1
Synonyms CRSBP1, HAR, XLKD1
Function Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
Cellular Location Membrane; Single-pass type I membrane protein Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand- dependent internalization and recycling at the cell surface
Tissue Location Mainly expressed in endothelial cells lining lymphatic vessels.
Research Areas
Citations (0)

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One of the key groups of molecules regulating leukocyte and tumour cell migration is the glycosaminoglycan hyaluronan (HA). In inflammation, the exit of leukocytes across vascular endothelium to the underlying tissues involves interactions with cell surface lectin-like receptors on the leukocytes that bind HA on the lumenal surface of the endothelium. During normal tissue homeostasis and after tissue injury, HA is mobilized from these sites through lymphatic vessels to the lymph nodes where it is degraded before entering the circulation for rapid uptake by the liver. Lymphatic vessel endothelial hyaluronan receptor (LYVE)-1 is a major receptor for HA on the lymph vessel wall. LYVE-1 is expressed primarily on lymphatic vessel endothelium and is likely to be involved in regulating the traffic of leucocytes and tumour cells to lymph nodes.


Jackson, D.G., Trends Cardiovasc. Med. 13(1):1-7 (2003).
Cursiefen, C., et al., Invest. Ophthalmol. Vis. Sci. 43(7):2127-2135 (2002).
Cunnick, G.H., et al., Biochem. Biophys. Res. Commun. 288(4):1043-1046 (2001).
Mouta Carreira, C., et al., Cancer Res. 61(22):8079-8084 (2001).
Banerji, S., et al., J. Cell Biol. 144(4):789-801 (1999).

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$ 325.00
$ 109.00
Cat# AP2015a
Availability: In Stock
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