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Neurogenin2 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Neurogenin2 Antibody (C-term) AP2023b
    The Neurogenin2 N-term polyclonal antibody (Cat. #AP2023b) is used in Western blot to detect Neurogenin2 in mouse liver tissue lysate.
  • WB - Neurogenin2 Antibody (C-term) AP2023b
    Neurogenin2 Antibody (D235) (Cat. #AP2023b) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the Neurogenin2 antibody detected the Neurogenin2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H2A3
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 242-272 aa
Additional Information
Other Names Neurogenin-2, NGN-2, Class A basic helix-loop-helix protein 8, bHLHa8, Protein atonal homolog 4, NEUROG2, ATOH4, BHLHA8, NGN2
Target/Specificity This Neurogenin2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-272 amino acids from the C-terminal region of human Neurogenin2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNeurogenin2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ATOH4, BHLHA8, NGN2
Function Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981} EMBL; BC036847; AAH36847.1; -; mRNA EMBL; AF303002; AAG40770.1; -; Genomic_DNA CCDS; CCDS3698.1; - RefSeq; NP_076924.1; NM_024019.3 UniGene; Hs.744415; - ProteinModelPortal; Q9H2A3; - SMR; Q9H2A3; - BioGrid; 122020; 2 IntAct; Q9H2A3; 2 MINT; Q9H2A3; - STRING; 9606.ENSP00000317333; - iPTMnet; Q9H2A3; - PhosphoSitePlus; Q9H2A3; - BioMuta; NEUROG2; - DMDM; 60392832; - PaxDb; Q9H2A3; - PRIDE; Q9H2A3; - ProteomicsDB; 80519; - Ensembl; ENST00000313341; ENSP00000317333; ENSG00000178403 GeneID; 63973; - KEGG; hsa:63973; - UCSC; uc003ias.3; human CTD; 63973; - DisGeNET; 63973; - EuPathDB; HostDB:ENSG00000178403.3; - GeneCards; NEUROG2; - HGNC; HGNC:13805; NEUROG2 HPA; CAB012342; - MIM; 606624; gene neXtProt; NX_Q9H2A3; - OpenTargets; ENSG00000178403; - PharmGKB; PA31570; - eggNOG; ENOG410IQ4B; Eukaryota eggNOG; ENOG410XZ4C; LUCA GeneTree; ENSGT00680000099860; - HOGENOM; HOG000063655; - HOVERGEN; HBG101129; - InParanoid; Q9H2A3; - KO; K09082; - OMA; SDMDYWQ; - OrthoDB; EOG091G0PNH; - PhylomeDB; Q9H2A3; - TreeFam; TF315153; - SIGNOR; Q9H2A3; - GeneWiki; NEUROG2; - GenomeRNAi; 63973; - PRO; PR:Q9H2A3; - Proteomes; UP000005640; Chromosome 4 Bgee; ENSG00000178403; - CleanEx; HS_NEUROG2; - Genevisible; Q9H2A3; HS GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell GO; GO:0070888; F:E-box binding; ISS:UniProtKB GO; GO:0046983; F:protein dimerization activity; IEA:InterPro GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0030182; P:neuron differentiation; IEA:InterPro GO; GO:0051091; P:positive regulation of DNA binding transcription factor activity; ISS:UniProtKB GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW CDD; cd00083; HLH; 1 Gene3D;; -; 1 InterPro; IPR011598; bHLH_dom InterPro; IPR036638; HLH_DNA-bd_sf InterPro; IPR032655; Ngn2 PANTHER; PTHR19290:SF105; PTHR19290:SF105; 1 Pfam; PF00010; HLH; 1 SMART; SM00353; HLH; 1 SUPFAM; SSF47459; SSF47459; 1 PROSITE; PS50888; BHLH; 1 2: Evidence at transcript level; Activator; Complete proteome; Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus; Reference proteome; Transcription; Transcription regulation CHAIN 1 272 Neurogenin-2 /FTId=PRO_0000127400 DOMAIN 112 164 bHLH. {ECO:0000255|PROSITE- ProRule:PRU00981} COMPBIAS 198 246 Ser-rich SEQUENCE 272 AA; 28621 MW; 57AB37CC4A9E15FC CRC64; MFVKSETLEL KEEEDVLVLL GSASPALAAL TPLSSSADEE EEEEPGASGG ARRQRGAEAG QGARGGVAAG AEGCRPARLL GLVHDCKRRP SRARAVSRGA KTAETVQRIK KTRRLKANNR ERNRMHNLNA ALDALREVLP TFPEDAKLTK IETLRFAHNY IWALTETLRL ADHCGGGGGG LPGALFSEAV LLSPGGASAA LSSSGDSPSP ASTWSCTNSP APSSSVSSNS TSPYSCTLSP ASPAGSDMDY WQPPPPDKHR YAPHLPIARD CI
Research Areas
Citations (0)

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Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis from migratory neural crest cells. In the course of mouse neurogenesis, Ngn2 and Ngn1 are expressed in distinct progenitor populations residing in the central and peripheral nervous systems. Mutation analyses demonstrate that Ngn1 is required for the determination of neuronal precursors for proximal cranial sensory ganglia and that Ngn2 is necessary for the determination of precursors for epibranchial placode-derived sensory neurons.


Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).

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$ 325.00
$ 109.00
Cat# AP2023b
Availability: In Stock
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