|Application ||WB, E|
|Calculated MW||35619 Da|
|Antigen Region||293-321 aa|
|Other Names||Sideroflexin-1, Tricarboxylate carrier protein, TCC, SFXN1|
|Target/Specificity||This SFXN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-321 amino acids from the C-terminal region of human SFXN1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SFXN1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778). Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778). Transports both D-serine and L-serine (PubMed:30442778). Also able to transport other amino- acids, such as alanine (PubMed:30442778). May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity).|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in tissues with high one- carbon metabolism activity, such as blood, liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
Might be involved in the transport of a component required for iron utilization into or out of the mitochondria.
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Siculella, L., et al. FEBS Lett. 578(3):280-284(2004)
Siculella, L., et al. J. Lipid Res. 45(7):1333-1340(2004)
Giudetti, A.M., et al. J. Lipid Res. 44(11):2135-2141(2003)
Miyake, S., et al. Biochem. Biophys. Res. Commun. 295(2):463-468(2002)
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