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PROX1 Antibody (S197)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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  • WB - PROX1 Antibody (S197) AP2035d
    PROX-1 Antibody (S197) (Cat. #AP2035d) western blot analysis in SH-SY5Y cell line lysates (35ug/lane).This demonstrates the PROX-1 antibody detected the PROX-1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92786
Other Accession P48437, NP_002754
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 83203 Da
Antigen Region 175-206 aa
Additional Information
Gene ID 5629
Other Names Prospero homeobox protein 1, Homeobox prospero-like protein PROX1, PROX-1, PROX1
Target/Specificity This PROX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-206 amino acids from human PROX1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPROX1 Antibody (S197) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PROX1
Function Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
Cellular Location Nucleus {ECO:0000250|UniProtKB:P48437}. Note=RORG promotes its nuclear localization {ECO:0000250|UniProtKB:P48437}
Tissue Location Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas
Research Areas
Citations (0)

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The expression pattern of Prox1 suggests that it has a role in a variety of embryonic tissues, including lens. Prox mRNA is present in many different human tissues with lens demonstrating the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens. Prox1 is expressed in a subpopulation of endothelial cells that by budding and sprouting give rise to the lymphatic system. Prox1 appears to be a specific and required regulator of the development of the lymphatic system. Prox1 also has been documented to be required for hepatocyte migration in the mouse. Loss of Prox1 results in a smaller liver with a reduced population of clustered hepatocytes. The homeodomain protein Prox1 regulates the egress of progenitor cells from the cell cycle in the embryonic mouse retina. Cells lacking Prox1 are less likely to stop dividing, and ectopic expression of Prox1 forces progenitor cells to exit the cell cycle. Prox1 acts as a key participant in progenitor-cell proliferation and cell-fate determination in the vertebrate retina.


Nagai, H., et al., Genes Chromosomes Cancer 38(1):13-21 (2003).
Dyer, M.A., et al., Nat. Genet. 34(1):53-58 (2003).
Hong, Y.K., et al., Dev. Dyn. 225(3):351-357 (2002).
Petrova, T.V., et al., EMBO J. 21(17):4593-4599 (2002).
Mouta Carreira, C., et al., Cancer Res. 61(22):8079-8084 (2001).

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$ 325.00
$ 109.00
Cat# AP2035d
Availability: In Stock
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