|Application ||WB, E|
|Calculated MW||94983 Da|
|Antigen Region||661-687 aa|
|Other Names||N-acetyltransferase ESCO1, 231-, CTF7 homolog 1, Establishment factor-like protein 1, EFO1p, hEFO1, Establishment of cohesion 1 homolog 1, ECO1 homolog 1, ESO1 homolog 1, ESCO1, EFO1, KIAA1911|
|Target/Specificity||This ESCO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 661-687 amino acids from the C-terminal region of human ESCO1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ESCO1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053).|
|Cellular Location||Nucleus. Chromosome. Note=Nuclear at interphase, associated with chromosomes during mitosis|
|Tissue Location||Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Highly expressed in muscle.|
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Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3.
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