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APBB3 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - APBB3 Antibody (Center) AP20461c
    APBB3 Antibody (Center) (Cat. #AP20461c) western blot analysis in A431,Hela,K562 cell line lysates (35ug/lane).This demonstrates the APBB3 antibody detected the APBB3 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95704
Other Accession O35827, Q8R1C9
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 187-214 aa
Additional Information
Other Names Amyloid beta A4 precursor protein-binding family B member 3, Protein Fe65-like 2, Fe65L2, APBB3, FE65L2
Target/Specificity This APBB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-214 amino acids from the Central region of human APBB3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAPBB3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name APBB3
Synonyms FE65L2
Function May modulate the internalization of amyloid-beta precursor protein.
Cellular Location Cytoplasm. Nucleus Isoform I-245: Nucleus.
Tissue Location Expressed in various tissues, highest expression in brain. EMBL; AB018247; BAA35188.1; -; mRNA EMBL; AB024745; BAA78674.1; -; Genomic_DNA EMBL; AB049618; BAB40806.1; -; mRNA EMBL; AB061224; BAB71767.1; -; mRNA EMBL; AF224708; AAF65172.1; -; mRNA EMBL; AF224709; AAF65173.1; -; mRNA EMBL; AF224710; AAF65174.1; -; mRNA EMBL; AF224711; AAF65175.1; -; mRNA EMBL; AK075280; BAG52101.1; -; mRNA EMBL; AC011399; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AC116353; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471062; EAW62041.1; -; Genomic_DNA EMBL; BC125187; AAI25188.1; -; mRNA CCDS; CCDS4227.1; -. [O95704-4] CCDS; CCDS4228.1; -. [O95704-3] CCDS; CCDS4229.1; -. [O95704-1] CCDS; CCDS47279.1; -. [O95704-2] RefSeq; NP_006042.3; NM_006051.3. [O95704-4] RefSeq; NP_573418.2; NM_133172.2. [O95704-3] RefSeq; NP_573419.2; NM_133173.2. [O95704-1] RefSeq; NP_573420.2; NM_133174.2. [O95704-2] UniGene; Hs.529449; - PDB; 2DYQ; X-ray; 3.10 A; A=281-417 PDB; 2YSC; NMR; -; A=30-61 PDBsum; 2DYQ; - PDBsum; 2YSC; - ProteinModelPortal; O95704; - SMR; O95704; - BioGrid; 115593; 25 IntAct; O95704; 7 MINT; O95704; - STRING; 9606.ENSP00000346378; - iPTMnet; O95704; - PhosphoSitePlus; O95704; - BioMuta; APBB3; - PaxDb; O95704; - PeptideAtlas; O95704; - PRIDE; O95704; - ProteomicsDB; 51002; - ProteomicsDB; 51003; -. [O95704-2] ProteomicsDB; 51004; -. [O95704-3] ProteomicsDB; 51005; -. [O95704-4] Ensembl; ENST00000354402; ENSP00000346378; ENSG00000113108. [O95704-4] Ensembl; ENST00000356738; ENSP00000349177; ENSG00000113108. [O95704-3] Ensembl; ENST00000357560; ENSP00000350171; ENSG00000113108. [O95704-1] Ensembl; ENST00000412920; ENSP00000402591; ENSG00000113108. [O95704-2] Ensembl; ENST00000467078; ENSP00000422718; ENSG00000113108. [O95704-6] Ensembl; ENST00000509914; ENSP00000426107; ENSG00000113108. [O95704-5] GeneID; 10307; - KEGG; hsa:10307; - UCSC; uc003lgd.2; human. [O95704-1] CTD; 10307; - DisGeNET; 10307; - EuPathDB; HostDB:ENSG00000113108.17; - GeneCards; APBB3; - HGNC; HGNC:20708; APBB3 HPA; HPA005571; - MIM; 602711; gene neXtProt; NX_O95704; - OpenTargets; ENSG00000113108; - PharmGKB; PA134958636; - eggNOG; ENOG410IEKA; Eukaryota eggNOG; ENOG410YEVS; LUCA GeneTree; ENSGT00390000000002; - HOGENOM; HOG000033983; - HOVERGEN; HBG050524; - InParanoid; O95704; - OMA; CQPHAGG; - OrthoDB; EOG091G04HV; - PhylomeDB; O95704; - TreeFam; TF314331; - SignaLink; O95704; - ChiTaRS; APBB3; human EvolutionaryTrace; O95704; - GeneWiki; APBB3; - GenomeRNAi; 10307; - PRO; PR:O95704; - Proteomes; UP000005640; Chromosome 5 Bgee; ENSG00000113108; - CleanEx; HS_APBB3; - ExpressionAtlas; O95704; baseline and differential Genevisible; O95704; HS GO; GO:0015629; C:actin cytoskeleton; IDA:HPA GO; GO:0005737; C:cytoplasm; IBA:GO_Central GO; GO:0005829; C:cytosol; IDA:HPA GO; GO:0005634; C:nucleus; IBA:GO_Central GO; GO:0001540; F:amyloid-beta binding; IBA:GO_Central GO; GO:0008134; F:transcription factor binding; IBA:GO_Central GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central CDD; cd00201; WW; 1 Gene3D;; -; 2 InterPro; IPR011993; PH-like_dom_sf InterPro; IPR006020; PTB/PI_dom InterPro; IPR001202; WW_dom InterPro; IPR036020; WW_dom_sf Pfam; PF00640; PID; 1 SMART; SM00462; PTB; 2 SMART; SM00456; WW; 1 SUPFAM; SSF51045; SSF51045; 1 PROSITE; PS01179; PID; 2 PROSITE; PS01159; WW_DOMAIN_1; 1 PROSITE; PS50020; WW_DOMAIN_2; 1 1: Evidence at protein level; 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome; Repeat CHAIN 1 486 Amyloid-beta A4 precursor protein-binding family B member 3 /FTId=PRO_0000076054 DOMAIN 29 61 WW. {ECO:0000255|PROSITE- ProRule:PRU00224} DOMAIN 113 280 PID 1. {ECO:0000255|PROSITE- ProRule:PRU00148} DOMAIN 285 440 PID 2. {ECO:0000255|PROSITE- ProRule:PRU00148} VAR_SEQ 196 214 VHIRVWGVGSSKGRDRDFA -> AVIPTDADPQYLNPWTQI L (in isoform I-214) /FTId=VSP_047811 VAR_SEQ 210 245 DRDFAFVASDKDSCMLKCHVFCCDVPAKAIASALHG -> S SDVDPGLLPLPGPALVGEGGPSSAGTVWGESERLG (in isoform I-245) /FTId=VSP_047812 VAR_SEQ 210 211 Missing (in isoform I) {ECO:0000303|PubMed:10081969, ECO:0000303|Ref.4} /FTId=VSP_006799 VAR_SEQ 210 210 D -> PISAPA (in isoform III) {ECO:0000303|Ref.4} /FTId=VSP_006800 VAR_SEQ 210 210 D -> DSPISAPA (in isoform IV) {ECO:0000303|Ref.4} /FTId=VSP_006801 VAR_SEQ 215 486 Missing (in isoform I-214) /FTId=VSP_047813 VAR_SEQ 246 486 Missing (in isoform I-245) /FTId=VSP_047814 VARIANT 165 165 G -> R (in dbSNP:rs7715021) /FTId=VAR_029518 VARIANT 231 231 C -> R (in dbSNP:rs250430) {ECO:0000269|PubMed:10081969, ECO:0000269|PubMed:10329396, ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15372022, ECO:0000269|Ref.4} /FTId=VAR_024702 STRAND 35 40 {ECO:0000244|PDB:2YSC} STRAND 43 51 {ECO:0000244|PDB:2YSC} STRAND 54 57 {ECO:0000244|PDB:2YSC} STRAND 292 304 {ECO:0000244|PDB:2DYQ} HELIX 307 318 {ECO:0000244|PDB:2DYQ} STRAND 327 333 {ECO:0000244|PDB:2DYQ} STRAND 335 342 {ECO:0000244|PDB:2DYQ} STRAND 354 358 {ECO:0000244|PDB:2DYQ} HELIX 359 361 {ECO:0000244|PDB:2DYQ} STRAND 362 367 {ECO:0000244|PDB:2DYQ} STRAND 373 379 {ECO:0000244|PDB:2DYQ} STRAND 381 383 {ECO:0000244|PDB:2DYQ} STRAND 385 391 {ECO:0000244|PDB:2DYQ} HELIX 397 415 {ECO:0000244|PDB:2DYQ} SEQUENCE 486 AA; 52585 MW; 553DFB4D8655EFA1 CRC64; MLGKDYMLAI ILVNCDDDLW GDHSLEVEAG LPPGWRKIHD AAGTYYWHVP SGSTQWQRPT WELGDAEDPG TGTEGIWGLR PPKGRSFSSL ESSLDRSNSL SWYGGESYIQ SMEPGAKCFA VRSLGWVEVP EEDLAPGKSS IAVNNCIQQL AQTRSRSQPP DGAWGEGQNM LMILKKDAMS LVNPLDHSLI HCQPLVHIRV WGVGSSKGRD RDFAFVASDK DSCMLKCHVF CCDVPAKAIA SALHGLCAQI LSERVEVSGD ASCCSPDPIS PEDLPRQVEL LDAVSQAAQK YEALYMGTLP VTKAMGMDVL NEAIGTLTAR GDRNAWVPTM LSVSDSLMTA HPIQAEASTE EEPLWQCPVR LVTFIGVGRD PHTFGLIADL GRQSFQCAAF WCQPHAGGLS EAVQAACMVQ YQKCLVASAA RGKAWGAQAR ARLRLKRTSS MDSPGGPLPL PLLKGGVGGA GATPRKRGVF SFLDAFRLKP SLLHMP
Research Areas
Citations (0)

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May modulate the internalization of beta-amyloid precursor protein.


Tanahashi H., et al. Neurosci. Lett. 261:143-146(1999).
Tanahashi H., et al. Biochem. Biophys. Res. Commun. 258:385-389(1999).
Mao Y.M., et al. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
Ota T., et al. Nat. Genet. 36:40-45(2004).
Schmutz J., et al. Nature 431:268-274(2004).

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Cat# AP20461c
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